The adipokine/ceramide axis: Key aspects of insulin sensitization

Jonathan Y. Xia, Thomas S. Morley, Philipp E. Scherer

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


Until recently, sphingolipid physiology was primarily the domain of oncologists and immunologists. However, mounting evidence implicates ceramides and their derivatives in various aspects of metabolism via directly impacting the insulin receptor as well as modulating cell survival and proliferation. More recent observations suggest a strong link between a number of adipokines and ceramide catabolism. Here, we aim to briefly review the available data on the established metabolic effects of sphingolipids in various cell types and will discuss how adipokines exert a critical influence on the steady state levels of these lipid mediators.

Original languageEnglish (US)
Pages (from-to)130-139
Number of pages10
Issue number1
StatePublished - Jan 2014


  • Ceramide target tissues
  • Ceramides
  • Insulin sensitivity
  • Plasma ceramide levels
  • Sphingolipids

ASJC Scopus subject areas

  • Biochemistry


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