TY - JOUR
T1 - The Adipocyte as an Endocrine Cell
AU - Halberg, Nils
AU - Wernstedt-Asterholm, Ingrid
AU - Scherer, Philipp E.
PY - 2008/9
Y1 - 2008/9
N2 - Adipose tissue contains many cell types. Among the more abundant are adipocytes, preadipocytes, immune cells, and endothelial cells. During times of excess caloric intake, these cells have to adjust and remodel to accommodate the increased demand for triglyceride storage. Based on a comprehensive analysis of the total adipose tissue secretome, this article focuses on three areas of adipokine biology: (1) How does the adipocyte interact with the extracellular matrix over the course of obestiy? (2) Does the adipocyte, per se, play a role in the innate immune response? (3) How is the angiogenic profile of adipose tissue linked to the development of insulin resistance? The authors present a comprehensive overview of all of the currently available secreted adipose tissue products that have been identified at the protein level.
AB - Adipose tissue contains many cell types. Among the more abundant are adipocytes, preadipocytes, immune cells, and endothelial cells. During times of excess caloric intake, these cells have to adjust and remodel to accommodate the increased demand for triglyceride storage. Based on a comprehensive analysis of the total adipose tissue secretome, this article focuses on three areas of adipokine biology: (1) How does the adipocyte interact with the extracellular matrix over the course of obestiy? (2) Does the adipocyte, per se, play a role in the innate immune response? (3) How is the angiogenic profile of adipose tissue linked to the development of insulin resistance? The authors present a comprehensive overview of all of the currently available secreted adipose tissue products that have been identified at the protein level.
UR - http://www.scopus.com/inward/record.url?scp=50449100949&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=50449100949&partnerID=8YFLogxK
U2 - 10.1016/j.ecl.2008.07.002
DO - 10.1016/j.ecl.2008.07.002
M3 - Review article
C2 - 18775362
AN - SCOPUS:50449100949
SN - 0889-8529
VL - 37
SP - 753
EP - 768
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
IS - 3
ER -