Keratinocytes play different roles in normal and wounded skin. In normal skin, these cells are specialized for differentiation. In wounded skin, they are specialized for migration. This article discusses the idea that migratory-competent keratinocytes are “activated.” Changes that characterize the activation process include increased cell attachment, spreading, focal adhesion formation, and migration. In part, these changes can be explained by enhanced expression of α5 integrin subunits and reorganization of β1 integrin subunits.
|Original language||English (US)|
|Journal||Journal of Trauma - Injury, Infection and Critical Care|
|State||Published - Dec 1990|
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine