TGF-β regulation by Emilin1: New links in the etiology of hypertension

Malavika Raman; Melanie H. Cobb

doi:10.1016/j.cell.2006.02.031

TGF-β regulation by Emilin1: New links in the etiology of hypertension

Malavika Raman, Melanie H. Cobb

Research output: Contribution to journal › Short survey › peer-review

18 Scopus citations

Abstract

Hypertension is a complex disease influenced by multiple genetic and environmental factors. The TGF-β signaling pathway has a long recognized role in blood pressure homeostasis. In this issue of Cell, Zacchigna et al. (2006) report that the secreted protein Emilin1 is a negative regulator of TGF-β signaling. Emilin1 knockout mice display elevated blood pressure due to increased TGF-β signaling in the vasculature.

Original language	English (US)
Pages (from-to)	893-895
Number of pages	3
Journal	Cell
Volume	124
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2006.02.031
State	Published - Mar 10 2006

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2006.02.031

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title = "TGF-β regulation by Emilin1: New links in the etiology of hypertension",

abstract = "Hypertension is a complex disease influenced by multiple genetic and environmental factors. The TGF-β signaling pathway has a long recognized role in blood pressure homeostasis. In this issue of Cell, Zacchigna et al. (2006) report that the secreted protein Emilin1 is a negative regulator of TGF-β signaling. Emilin1 knockout mice display elevated blood pressure due to increased TGF-β signaling in the vasculature.",

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T2 - New links in the etiology of hypertension

AU - Raman, Malavika

AU - Cobb, Melanie H.

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N2 - Hypertension is a complex disease influenced by multiple genetic and environmental factors. The TGF-β signaling pathway has a long recognized role in blood pressure homeostasis. In this issue of Cell, Zacchigna et al. (2006) report that the secreted protein Emilin1 is a negative regulator of TGF-β signaling. Emilin1 knockout mice display elevated blood pressure due to increased TGF-β signaling in the vasculature.

AB - Hypertension is a complex disease influenced by multiple genetic and environmental factors. The TGF-β signaling pathway has a long recognized role in blood pressure homeostasis. In this issue of Cell, Zacchigna et al. (2006) report that the secreted protein Emilin1 is a negative regulator of TGF-β signaling. Emilin1 knockout mice display elevated blood pressure due to increased TGF-β signaling in the vasculature.

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JO - Cell

JF - Cell

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ER -

TGF-β regulation by Emilin1: New links in the etiology of hypertension

Abstract

ASJC Scopus subject areas

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