@article{5f0b4f82dd1747acba5e5e886fc64f50,
title = "Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery",
abstract = "Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infrared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, from 80 nm to 140 nm, during a temperature increase from 40 °C to 65 °C.",
author = "Shawn He and George Tourkakis and Oleg Berezin and Nikolay Gerasimchuk and Hairong Zhang and Haiying Zhou and Asaf Izraely and Akers, {Walter J.} and Berezin, {Mikhail Y.}",
note = "Funding Information: We thank the Alvin J. Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital in St. Louis, Mo., for the use of the Siteman Flow Cytometry Core. The Siteman Cancer Center is supported in part by an NCI Cancer Center Support Grant #P30 CA91842. We thank the financial support from Missouri EPSCoR Program under NSF Foundation's Research Infrastructure Improvement Award #IIA-1355406. This work was performed in part at the Nano Research Facility (NRF), a member of the National Nanotechnology Infrastructure Network (NNIN), which is supported by the National Science Foundation under Grant No. ECS- 0335765. NRF is part of the School of Engineering and Applied Science at Washington University in St. Louis. We also thank the Washington University Optical Spectroscopy Core facility (NIH 1S10RR031621-01) for spectroscopy measurements. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",
year = "2016",
month = apr,
day = "14",
doi = "10.1039/c6tc00122j",
language = "English (US)",
volume = "4",
pages = "3028--3035",
journal = "Journal of Materials Chemistry C",
issn = "2050-7526",
publisher = "Royal Society of Chemistry",
number = "14",
}