Telomeres and telomerase

N. M V Gomes; J. W. Shay; W. E. Wright

doi:10.1007/978-90-481-3465-6_11

Telomeres and telomerase

N. M V Gomes, J. W. Shay, W. E. Wright

Research output: Chapter in Book/Report/Conference proceeding › Chapter

12 Scopus citations

Abstract

Telomere-based replicative senescence is thought to function as a potent mechanism of tumor protection in humans. Whether this mechanism is conserved in other species is still unclear. In this review we present an inter-species critical overview of some of the available literature on the fundamental biology of telomeres and telomerase during development, regeneration, cancer and aging of living organisms during their evolutionary journey through time.

Original language	English (US)
Title of host publication	The Comparative Biology of Aging
Publisher	Springer Netherlands
Pages	227-258
Number of pages	32
ISBN (Print)	9789048134649
DOIs	https://doi.org/10.1007/978-90-481-3465-6_11
State	Published - 2010

Keywords

Amphibians
Birds
Evolution
Fish
Invertebrates
Mammals
Telomerase
Telomeres
Vertebrates

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)

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10.1007/978-90-481-3465-6_11

Cite this

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AU - Shay, J. W.

AU - Wright, W. E.

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AB - Telomere-based replicative senescence is thought to function as a potent mechanism of tumor protection in humans. Whether this mechanism is conserved in other species is still unclear. In this review we present an inter-species critical overview of some of the available literature on the fundamental biology of telomeres and telomerase during development, regeneration, cancer and aging of living organisms during their evolutionary journey through time.

KW - Amphibians

KW - Birds

KW - Evolution

KW - Fish

KW - Invertebrates

KW - Mammals

KW - Telomerase

KW - Telomeres

KW - Vertebrates

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BT - The Comparative Biology of Aging

PB - Springer Netherlands

ER -

Telomeres and telomerase

Abstract

Keywords

ASJC Scopus subject areas

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