Telomerase: A target for cancer therapeutics

Jerry W. Shay; Woodring E. Wright

doi:10.1016/S1535-6108(02)00159-9

Telomerase: A target for cancer therapeutics

Jerry W. Shay, Woodring E. Wright

Research output: Contribution to journal › Review article › peer-review

303 Scopus citations

Abstract

The continuous growth of advanced malignancies almost universally correlates with the reactivation of telomerase. While there is still a great deal of basic and applied research to be done, telomerase remains a very attractive novel target for cancer therapeutics. In this review, we will discuss the challenges and the pros and cons of the most promising antitelomerase approaches currently being investigated.

Original language	English (US)
Pages (from-to)	257-265
Number of pages	9
Journal	Cancer Cell
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/S1535-6108(02)00159-9
State	Published - Oct 2002

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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10.1016/S1535-6108(02)00159-9

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title = "Telomerase: A target for cancer therapeutics",

abstract = "The continuous growth of advanced malignancies almost universally correlates with the reactivation of telomerase. While there is still a great deal of basic and applied research to be done, telomerase remains a very attractive novel target for cancer therapeutics. In this review, we will discuss the challenges and the pros and cons of the most promising antitelomerase approaches currently being investigated.",

author = "Shay, {Jerry W.} and Wright, {Woodring E.}",

note = "Funding Information: Support is acknowledged from the Ellison Medical Foundation, Geron Corporation, CA74908, CA70907, and NCI Contract CN-0501763-63. We thank Calvin Harley for critical discussions and Kent Thompson for help with the figure illustrations.",

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T2 - A target for cancer therapeutics

AU - Shay, Jerry W.

AU - Wright, Woodring E.

N1 - Funding Information: Support is acknowledged from the Ellison Medical Foundation, Geron Corporation, CA74908, CA70907, and NCI Contract CN-0501763-63. We thank Calvin Harley for critical discussions and Kent Thompson for help with the figure illustrations.

PY - 2002/10

Y1 - 2002/10

N2 - The continuous growth of advanced malignancies almost universally correlates with the reactivation of telomerase. While there is still a great deal of basic and applied research to be done, telomerase remains a very attractive novel target for cancer therapeutics. In this review, we will discuss the challenges and the pros and cons of the most promising antitelomerase approaches currently being investigated.

AB - The continuous growth of advanced malignancies almost universally correlates with the reactivation of telomerase. While there is still a great deal of basic and applied research to be done, telomerase remains a very attractive novel target for cancer therapeutics. In this review, we will discuss the challenges and the pros and cons of the most promising antitelomerase approaches currently being investigated.

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U2 - 10.1016/S1535-6108(02)00159-9

DO - 10.1016/S1535-6108(02)00159-9

M3 - Review article

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AN - SCOPUS:0036782884

SN - 1535-6108

VL - 2

SP - 257

EP - 265

JO - Cancer Cell

JF - Cancer Cell

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ER -

Telomerase: A target for cancer therapeutics

Abstract

ASJC Scopus subject areas

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