Team approach: Management of osteonecrosis in children with acute lymphoblastic leukemia

Lynne C. Jones, Sue C. Kaste, Seth E. Karol, Brian DeFeo, Harry K.W. Kim, Michael D. Neel, Adam S. Levin

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


With current treatments for acute lymphoblastic leukemia (ALL), the overall prognosis for survival is favorable. Increasing emphasis is placed on recognizing and managing the long-term consequences of ALL and its treatment, particularly involving osteonecrosis. Early osteonecrosis diagnosis and management may improve outcomes and is best accomplished through coordinated teams that may include hematologic oncologists, radiologists, orthopedic surgeons, physical therapists, and the patient and their family. Magnetic resonance imaging is the “gold standard” for diagnosis of early-stage and/or multifocal osteonecrosis. Treatments for osteonecrosis in ALL patients are risk stratified and may include observation, corticosteroid or chemotherapy adjustment, and pharmaceutical or surgical approaches.

Original languageEnglish (US)
Article numbere28509
JournalPediatric Blood and Cancer
Issue number11
StatePublished - Nov 1 2020
Externally publishedYes


  • acute lymphoblastic leukemia
  • diagnosis
  • magnetic resonance imaging
  • osteonecrosis
  • treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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