Abstract
From the earliest stages of embryogenesis and throughout life, transcriptional regulation is carefully orchestrated in order to generate, shape, and reshape the central nervous system (CNS). TAR DNA-binding protein 43 (TDP-43) is identified as a regulator of essential transcriptional events in the CNS. Evidence for its importance comes from the identification of TDP-43 protein aggregates and genetic mutations in patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Efforts are being made to learn more about the biological function of TDP-43 and gain a better understanding of its role in neurodegeneration. TDP-43 RNA targets and protein interactions have now been identified, and in vivo evidence shows that TDP-43 is essential in CNS development and function. This review will highlight aspects of these findings.
Original language | English (US) |
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Pages (from-to) | 589-594 |
Number of pages | 6 |
Journal | Biological Chemistry |
Volume | 393 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2012 |
Keywords
- Amyotrophic lateral sclerosis (ALS)
- Neural development
- PTPB2
- RIP-seq
- RNA binding protein
- TDP-43
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Clinical Biochemistry