Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease

Nitin J. Karandikar; Carol L. Vanderlugt; Jeffrey A. Bluestone; Stephen D. Miller

doi:10.1016/S0165-5728(98)00058-7

Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease

Nitin J. Karandikar, Carol L. Vanderlugt, Jeffrey A. Bluestone, Stephen D. Miller

Pathology

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

The B7/CD28:CTLA-4 costimulatory pathway plays a critical role in determining the fate of immmune responses (activation vs. down-regulation) and is a highly promising therapeutic target for treating autoimmune diseases. In this review, we highlight the mechanisms by which this costimulatory pathway operates emphasizing the role of the different components in the pathogenesis of relapsing experimental autoimmmune encephalomyelitis, a CD4 T cell-mediated autoimmune model of multiple sclerosis. The separate and distinct roles of B7-1, B7-2 and CTLA-4 in positive and negative regulation of autoimmune pathogenesis are considered and a working model is proposed.

Original language	English (US)
Pages (from-to)	10-18
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	89
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(98)00058-7
State	Published - Aug 14 1998

Keywords

B7/CD28:CTLA-4 costimulatory system
Central nervous system (CNS)
Experimental autoimmune encephalomyelitis (EAE)

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/S0165-5728(98)00058-7

Cite this

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abstract = "The B7/CD28:CTLA-4 costimulatory pathway plays a critical role in determining the fate of immmune responses (activation vs. down-regulation) and is a highly promising therapeutic target for treating autoimmune diseases. In this review, we highlight the mechanisms by which this costimulatory pathway operates emphasizing the role of the different components in the pathogenesis of relapsing experimental autoimmmune encephalomyelitis, a CD4 T cell-mediated autoimmune model of multiple sclerosis. The separate and distinct roles of B7-1, B7-2 and CTLA-4 in positive and negative regulation of autoimmune pathogenesis are considered and a working model is proposed.",

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AU - Miller, Stephen D.

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Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease

Abstract

Keywords

ASJC Scopus subject areas

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