Nicotinamide adenine dinucleotide (NAD + ) metabolism is integrally connected with the mechanisms of action of radiation therapy and is altered in many radiation-resistant tumors. This makes NAD + metabolism an ideal target for therapies that increase radiation sensitivity and improve patient outcomes. This review provides an overview of NAD + metabolism in the context of the cellular response to ionizing radiation, as well as current therapies that target NAD + metabolism to enhance radiation therapy responses. Additionally, we summarize state-of-the-art methods for measuring, modeling, and manipulating NAD + metabolism, which are being used to identify novel targets in the NAD + metabolic network for therapeutic interventions in combination with radiation therapy.
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cancer Research