Targeting adipose tissue in the treatment of obesity-associated diabetes

Christine M. Kusminski; Perry E. Bickel; Philipp E. Scherer

doi:10.1038/nrd.2016.75

Targeting adipose tissue in the treatment of obesity-associated diabetes

Christine M. Kusminski, Perry E. Bickel, Philipp E. Scherer

Research output: Contribution to journal › Review article › peer-review

493 Scopus citations

Abstract

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 diabetes mellitus (T2DM). Although several US-approved treatments for obesity and T2DM exist, these are limited by adverse effects and a lack of effective long-term glucose control. In this Review, we provide an overview of the role of adipose tissue in metabolic homeostasis and assess emerging novel therapeutic strategies targeting adipose tissue, including adipokine-based strategies, promotion of white adipose tissue beiging as well as reduction of inflammation and fibrosis.

Original language	English (US)
Pages (from-to)	639-660
Number of pages	22
Journal	Nature Reviews Drug Discovery
Volume	15
Issue number	9
DOIs	https://doi.org/10.1038/nrd.2016.75
State	Published - Aug 30 2016

ASJC Scopus subject areas

Drug Discovery
Pharmacology

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10.1038/nrd.2016.75

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abstract = "Adipose tissue regulates numerous physiological processes, and its dysfunction in obese humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 diabetes mellitus (T2DM). Although several US-approved treatments for obesity and T2DM exist, these are limited by adverse effects and a lack of effective long-term glucose control. In this Review, we provide an overview of the role of adipose tissue in metabolic homeostasis and assess emerging novel therapeutic strategies targeting adipose tissue, including adipokine-based strategies, promotion of white adipose tissue beiging as well as reduction of inflammation and fibrosis.",

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Targeting adipose tissue in the treatment of obesity-associated diabetes

Abstract

ASJC Scopus subject areas

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