TY - JOUR
T1 - Takayasu arteritis
T2 - Challenges in diagnosis and management
AU - Kim, Esther S.H.
AU - Beckman, Joshua
N1 - Publisher Copyright:
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved.
PY - 2018/4
Y1 - 2018/4
N2 - Takayasu arteritis (TA) is a rare disease affecting chiefly young women, although it can affect both men and women and persons of many different ethnicities. TA carries a high morbidity rate, but importantly, overall mortality has declined over time such that the 15-year survival rate has increased from 82.9% for patients diagnosed between 1957 and 1975 to 96.5% for those diagnosed from 1976 to 1990. Severity of presenting arterial complications and delay to diagnosis have also decreased over the past decade owing to advances in non-invasive diagnostic imaging and the development of medical therapies. Despite these advances, there still remain significant gaps in the diagnosis and management of these complex patients. These gaps encompass the basic, yet extremely complex, tasks of defining a universally accepted diagnostic criterion, accurate assessment of disease activity and development of clinically meaningful and accurate outcome measures to guide necessary clinical trials for the management of these complex patients.
AB - Takayasu arteritis (TA) is a rare disease affecting chiefly young women, although it can affect both men and women and persons of many different ethnicities. TA carries a high morbidity rate, but importantly, overall mortality has declined over time such that the 15-year survival rate has increased from 82.9% for patients diagnosed between 1957 and 1975 to 96.5% for those diagnosed from 1976 to 1990. Severity of presenting arterial complications and delay to diagnosis have also decreased over the past decade owing to advances in non-invasive diagnostic imaging and the development of medical therapies. Despite these advances, there still remain significant gaps in the diagnosis and management of these complex patients. These gaps encompass the basic, yet extremely complex, tasks of defining a universally accepted diagnostic criterion, accurate assessment of disease activity and development of clinically meaningful and accurate outcome measures to guide necessary clinical trials for the management of these complex patients.
KW - aortitis
UR - http://www.scopus.com/inward/record.url?scp=85044831676&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044831676&partnerID=8YFLogxK
U2 - 10.1136/heartjnl-2016-310848
DO - 10.1136/heartjnl-2016-310848
M3 - Review article
C2 - 29175979
AN - SCOPUS:85044831676
SN - 1355-6037
VL - 104
SP - 558
EP - 565
JO - Heart
JF - Heart
IS - 7
ER -