Tachycardia-induced early afterdepolarizations: Insights into potential ionic mechanisms from computer simulations

Ray B. Huffaker, Richard Samade, James N. Weiss, Boris Kogan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Although early afterdepolarizations (EADs) are classically thought to occur at slow heart rates, mounting evidence suggests that EADs may also occur at rapid heart rates produced by tachyarrhythmias, due to Ca overload of the sarcoplasmic reticulum (SR) leading to spontaneous SR Ca release. We hypothesized that the mechanism of tachycardia-induced EADs depends on the spatial and temporal morphology of spontaneous SR Ca release, and tested this hypothesis in computer simulations using a ventricular action potential mathematical model. Using two previously suggested spontaneous release morphologies, we found two distinct tachycardia-induced EAD mechanisms: one mechanistically similar to bradycardia-induced EADs, the other to delayed afterdepolarizations (DADs).

Original languageEnglish (US)
Pages (from-to)1140-1151
Number of pages12
JournalComputers in Biology and Medicine
Issue number11-12
StatePublished - Nov 2008
Externally publishedYes


  • Computer simulation
  • Early afterdepolarizations
  • Mathematical modeling
  • Spontaneous release
  • Tachyarrhythmias

ASJC Scopus subject areas

  • Computer Science Applications
  • Health Informatics


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