Tachycardia-induced early afterdepolarizations: Insights into potential ionic mechanisms from computer simulations

Ray B. Huffaker; Richard Samade; James N. Weiss; Boris Kogan

doi:10.1016/j.compbiomed.2008.08.010

Tachycardia-induced early afterdepolarizations: Insights into potential ionic mechanisms from computer simulations

Ray B. Huffaker, Richard Samade, James N. Weiss, Boris Kogan

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Although early afterdepolarizations (EADs) are classically thought to occur at slow heart rates, mounting evidence suggests that EADs may also occur at rapid heart rates produced by tachyarrhythmias, due to Ca overload of the sarcoplasmic reticulum (SR) leading to spontaneous SR Ca release. We hypothesized that the mechanism of tachycardia-induced EADs depends on the spatial and temporal morphology of spontaneous SR Ca release, and tested this hypothesis in computer simulations using a ventricular action potential mathematical model. Using two previously suggested spontaneous release morphologies, we found two distinct tachycardia-induced EAD mechanisms: one mechanistically similar to bradycardia-induced EADs, the other to delayed afterdepolarizations (DADs).

Original language	English (US)
Pages (from-to)	1140-1151
Number of pages	12
Journal	Computers in Biology and Medicine
Volume	38
Issue number	11-12
DOIs	https://doi.org/10.1016/j.compbiomed.2008.08.010
State	Published - Nov 2008
Externally published	Yes

Keywords

Computer simulation
Early afterdepolarizations
Mathematical modeling
Spontaneous release
Tachyarrhythmias

ASJC Scopus subject areas

Health Informatics
Computer Science Applications

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10.1016/j.compbiomed.2008.08.010

Cite this

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title = "Tachycardia-induced early afterdepolarizations: Insights into potential ionic mechanisms from computer simulations",

abstract = "Although early afterdepolarizations (EADs) are classically thought to occur at slow heart rates, mounting evidence suggests that EADs may also occur at rapid heart rates produced by tachyarrhythmias, due to Ca overload of the sarcoplasmic reticulum (SR) leading to spontaneous SR Ca release. We hypothesized that the mechanism of tachycardia-induced EADs depends on the spatial and temporal morphology of spontaneous SR Ca release, and tested this hypothesis in computer simulations using a ventricular action potential mathematical model. Using two previously suggested spontaneous release morphologies, we found two distinct tachycardia-induced EAD mechanisms: one mechanistically similar to bradycardia-induced EADs, the other to delayed afterdepolarizations (DADs).",

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T1 - Tachycardia-induced early afterdepolarizations

T2 - Insights into potential ionic mechanisms from computer simulations

AU - Huffaker, Ray B.

AU - Samade, Richard

AU - Weiss, James N.

AU - Kogan, Boris

PY - 2008/11

Y1 - 2008/11

N2 - Although early afterdepolarizations (EADs) are classically thought to occur at slow heart rates, mounting evidence suggests that EADs may also occur at rapid heart rates produced by tachyarrhythmias, due to Ca overload of the sarcoplasmic reticulum (SR) leading to spontaneous SR Ca release. We hypothesized that the mechanism of tachycardia-induced EADs depends on the spatial and temporal morphology of spontaneous SR Ca release, and tested this hypothesis in computer simulations using a ventricular action potential mathematical model. Using two previously suggested spontaneous release morphologies, we found two distinct tachycardia-induced EAD mechanisms: one mechanistically similar to bradycardia-induced EADs, the other to delayed afterdepolarizations (DADs).

AB - Although early afterdepolarizations (EADs) are classically thought to occur at slow heart rates, mounting evidence suggests that EADs may also occur at rapid heart rates produced by tachyarrhythmias, due to Ca overload of the sarcoplasmic reticulum (SR) leading to spontaneous SR Ca release. We hypothesized that the mechanism of tachycardia-induced EADs depends on the spatial and temporal morphology of spontaneous SR Ca release, and tested this hypothesis in computer simulations using a ventricular action potential mathematical model. Using two previously suggested spontaneous release morphologies, we found two distinct tachycardia-induced EAD mechanisms: one mechanistically similar to bradycardia-induced EADs, the other to delayed afterdepolarizations (DADs).

KW - Computer simulation

KW - Early afterdepolarizations

KW - Mathematical modeling

KW - Spontaneous release

KW - Tachyarrhythmias

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Tachycardia-induced early afterdepolarizations: Insights into potential ionic mechanisms from computer simulations

Abstract

Keywords

ASJC Scopus subject areas

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