T cell-derived B cell growth (BCGF) and differentiation (BCDF) factors: Suppression of the activity of BCDF(μ) but not BCGF by murine bone marrow cells

J. E. Layton; J. W. Uhr; E. Pure; P. H. Krammer; E. S. Vitetta

T cell-derived B cell growth (BCGF) and differentiation (BCDF) factors: Suppression of the activity of BCDF(μ) but not BCGF by murine bone marrow cells

J. E. Layton, J. W. Uhr, E. Pure, P. H. Krammer, E. S. Vitetta

Research output: Contribution to journal › Article › peer-review

Abstract

We have used a system of polyclonal B cell activation to assess the suppressive effect of BM cells on proliferation and differentiation of B cells. In these studies we found that B cell proliferation induced by either LPS or anti-Ig (± T cell supernatants (SN) containing BDGF) is not affected by the addition of BM cells, whereas IgM antibody secretion induced by SN containing BCDF(μ) is strongly inhibited. These data suggest that BM cells do not inhibit clonal expansion of B cells but rather suppress terminal differentation induced either by a mitogen or by T cell-derived lymphokines.

Original language	English (US)
Pages (from-to)	2502-2504
Number of pages	3
Journal	Journal of Immunology
Volume	130
Issue number	6
State	Published - 1983

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

@article{145f1bdf02354a4f975ce956b1cdde3d,

title = "T cell-derived B cell growth (BCGF) and differentiation (BCDF) factors: Suppression of the activity of BCDF(μ) but not BCGF by murine bone marrow cells",

abstract = "We have used a system of polyclonal B cell activation to assess the suppressive effect of BM cells on proliferation and differentiation of B cells. In these studies we found that B cell proliferation induced by either LPS or anti-Ig (± T cell supernatants (SN) containing BDGF) is not affected by the addition of BM cells, whereas IgM antibody secretion induced by SN containing BCDF(μ) is strongly inhibited. These data suggest that BM cells do not inhibit clonal expansion of B cells but rather suppress terminal differentation induced either by a mitogen or by T cell-derived lymphokines.",

author = "Layton, {J. E.} and Uhr, {J. W.} and E. Pure and Krammer, {P. H.} and Vitetta, {E. S.}",

year = "1983",

language = "English (US)",

volume = "130",

pages = "2502--2504",

journal = "Journal of Immunology",

issn = "0022-1767",

publisher = "American Association of Immunologists",

number = "6",

}

TY - JOUR

T1 - T cell-derived B cell growth (BCGF) and differentiation (BCDF) factors

T2 - Suppression of the activity of BCDF(μ) but not BCGF by murine bone marrow cells

AU - Layton, J. E.

AU - Uhr, J. W.

AU - Pure, E.

AU - Krammer, P. H.

AU - Vitetta, E. S.

PY - 1983

Y1 - 1983

N2 - We have used a system of polyclonal B cell activation to assess the suppressive effect of BM cells on proliferation and differentiation of B cells. In these studies we found that B cell proliferation induced by either LPS or anti-Ig (± T cell supernatants (SN) containing BDGF) is not affected by the addition of BM cells, whereas IgM antibody secretion induced by SN containing BCDF(μ) is strongly inhibited. These data suggest that BM cells do not inhibit clonal expansion of B cells but rather suppress terminal differentation induced either by a mitogen or by T cell-derived lymphokines.

AB - We have used a system of polyclonal B cell activation to assess the suppressive effect of BM cells on proliferation and differentiation of B cells. In these studies we found that B cell proliferation induced by either LPS or anti-Ig (± T cell supernatants (SN) containing BDGF) is not affected by the addition of BM cells, whereas IgM antibody secretion induced by SN containing BCDF(μ) is strongly inhibited. These data suggest that BM cells do not inhibit clonal expansion of B cells but rather suppress terminal differentation induced either by a mitogen or by T cell-derived lymphokines.

UR - http://www.scopus.com/inward/record.url?scp=0020966282&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020966282&partnerID=8YFLogxK

M3 - Article

C2 - 6602166

AN - SCOPUS:0020966282

SN - 0022-1767

VL - 130

SP - 2502

EP - 2504

JO - Journal of Immunology

JF - Journal of Immunology

IS - 6

ER -

T cell-derived B cell growth (BCGF) and differentiation (BCDF) factors: Suppression of the activity of BCDF(μ) but not BCGF by murine bone marrow cells

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this