TY - JOUR
T1 - Systems approaches to unravel T cell function and therapeutic potential in autoimmune disease
AU - Salinas, Victor H.
AU - Stuve, Olaf
N1 - Publisher Copyright:
Copyright © 2021 by The American Association of Immunologists, Inc.
PY - 2021/2/15
Y1 - 2021/2/15
N2 - Producing Ag-specific immune responses constrained to target tissues or cells that can be engaged or disengaged at will is predicated on understanding the network of genes governing immune cell function, defining the rules underlying Ag specificity, and synthesizing the tools to engineer them. The successes and limitations of chimeric Ag receptor (CAR) T cells emphasize this goal, and advances in high-throughput sequencing, large-scale genomic screens, single-cell profiling, and genetic modification are providing the necessary data to bring it to fruition—including a broader application into the treatment of autoimmune diseases. In this review, we delve into the implementation of these developments, survey the relevant works, and propose a framework for generating the next generation of synthetic T cells informed by the principles learned from these systems approaches.
AB - Producing Ag-specific immune responses constrained to target tissues or cells that can be engaged or disengaged at will is predicated on understanding the network of genes governing immune cell function, defining the rules underlying Ag specificity, and synthesizing the tools to engineer them. The successes and limitations of chimeric Ag receptor (CAR) T cells emphasize this goal, and advances in high-throughput sequencing, large-scale genomic screens, single-cell profiling, and genetic modification are providing the necessary data to bring it to fruition—including a broader application into the treatment of autoimmune diseases. In this review, we delve into the implementation of these developments, survey the relevant works, and propose a framework for generating the next generation of synthetic T cells informed by the principles learned from these systems approaches.
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U2 - 10.4049/jimmunol.2000954
DO - 10.4049/jimmunol.2000954
M3 - Review article
C2 - 33526601
AN - SCOPUS:85100662981
SN - 0022-1767
VL - 206
SP - 669
EP - 675
JO - Journal of Immunology
JF - Journal of Immunology
IS - 4
ER -