TY - JOUR
T1 - Systemic Markers of Lung Function and Forced Expiratory Volume in 1 Second Decline across Diverse Cohorts
AU - Ngo, Debby
AU - Pratte, Katherine A.
AU - Flexeder, Claudia
AU - Petersen, Hans
AU - Dang, Hong
AU - Ma, Yanlin
AU - Keyes, Michelle J.
AU - Gao, Yan
AU - Deng, Shuliang
AU - Peterson, Bennet D.
AU - Farrell, Laurie A.
AU - Bhambhani, Victoria M.
AU - Palacios, Cesar
AU - Quadir, Juweria
AU - Gillenwater, Lucas
AU - Xu, Hanfei
AU - Emson, Claire
AU - Gieger, Christian
AU - Suhre, Karsten
AU - Graumann, Johannes
AU - Jain, Deepti
AU - Conomos, Matthew P.
AU - Tracy, Russell P.
AU - Guo, Xiuqing
AU - Liu, Yongmei
AU - Johnson, W. Craig
AU - Cornell, Elaine
AU - Durda, Peter
AU - Taylor, Kent D.
AU - Papanicolaou, George J.
AU - Rich, Stephen S.
AU - Rotter, Jerome I.
AU - Rennard, Steven I.
AU - Curtis, Jeffrey L.
AU - Woodruff, Prescott G.
AU - Comellas, Alejandro P.
AU - Silverman, Edwin K.
AU - Crapo, James D.
AU - Larson, Martin G.
AU - Vasan, Ramachandran S.
AU - Wang, Thomas J.
AU - Correa, Adolfo
AU - Sims, Mario
AU - Wilson, James G.
AU - Gerszten, Robert E.
AU - O’Connor, George T.
AU - Barr, R. Graham
AU - Couper, David
AU - Dupuis, Josée
AU - Manichaikul, Ani
AU - O’Neal, Wanda K.
AU - Tesfaigzi, Yohannes
AU - Schulz, Holger
AU - Bowler, Russell P.
N1 - Publisher Copyright:
Copyright © 2023 by the American Thoracic Society.
PY - 2023/8
Y1 - 2023/8
N2 - Rationale: Chronic obstructive pulmonary disease (COPD) is a complex disease characterized by airway obstruction and accelerated lung function decline. Our understanding of systemic protein biomarkers associated with COPD remains incomplete. Objectives: To determine what proteins and pathways are associated with impaired pulmonary function in a diverse population. Methods: We studied 6,722 participants across six cohort studies with both aptamer-based proteomic and spirometry data (4,566 predominantly White participants in a discovery analysis and 2,156 African American cohort participants in a validation). In linear regression models, we examined protein associations with baseline forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (FVC). In linear mixed effects models, we investigated the associations of baseline protein levels with rate of FEV1 decline (ml/yr) in 2,777 participants with up to 7 years of follow-up spirometry. Results: We identified 254 proteins associated with FEV1 in our discovery analyses, with 80 proteins validated in the Jackson Heart Study. Novel validated protein associations include kallistatin serine protease inhibitor, growth differentiation factor 2, and tumor necrosis factor-like weak inducer of apoptosis (discovery b = 0.0561, Q = 4.05 3 10210; b = 0.0421, Q = 1.12 3 1023; and b = 0.0358, Q = 1.67 3 1023, respectively). In longitudinal analyses within cohorts with follow-up spirometry, we identified 15 proteins associated with FEV1 decline (Q, 0.05), including elafin leukocyte elastase inhibitor and mucin-associated TFF2 (trefoil factor 2; b = 24.3 ml/yr, Q = 0.049; b = 26.1 ml/yr, Q = 0.032, respectively). Pathways and processes highlighted by our study include aberrant extracellular matrix remodeling, enhanced innate immune response, dysregulation of angiogenesis, and coagulation. Conclusions: In this study, we identify and validate novel biomarkers and pathways associated with lung function traits in a racially diverse population. In addition, we identify novel protein markers associated with FEV1 decline. Several protein findings are supported by previously reported genetic signals, highlighting the plausibility of certain biologic pathways. These novel proteins might represent markers for risk stratification, as well as novel molecular targets for treatment of COPD.
AB - Rationale: Chronic obstructive pulmonary disease (COPD) is a complex disease characterized by airway obstruction and accelerated lung function decline. Our understanding of systemic protein biomarkers associated with COPD remains incomplete. Objectives: To determine what proteins and pathways are associated with impaired pulmonary function in a diverse population. Methods: We studied 6,722 participants across six cohort studies with both aptamer-based proteomic and spirometry data (4,566 predominantly White participants in a discovery analysis and 2,156 African American cohort participants in a validation). In linear regression models, we examined protein associations with baseline forced expiratory volume in 1 second (FEV1) and FEV1/forced vital capacity (FVC). In linear mixed effects models, we investigated the associations of baseline protein levels with rate of FEV1 decline (ml/yr) in 2,777 participants with up to 7 years of follow-up spirometry. Results: We identified 254 proteins associated with FEV1 in our discovery analyses, with 80 proteins validated in the Jackson Heart Study. Novel validated protein associations include kallistatin serine protease inhibitor, growth differentiation factor 2, and tumor necrosis factor-like weak inducer of apoptosis (discovery b = 0.0561, Q = 4.05 3 10210; b = 0.0421, Q = 1.12 3 1023; and b = 0.0358, Q = 1.67 3 1023, respectively). In longitudinal analyses within cohorts with follow-up spirometry, we identified 15 proteins associated with FEV1 decline (Q, 0.05), including elafin leukocyte elastase inhibitor and mucin-associated TFF2 (trefoil factor 2; b = 24.3 ml/yr, Q = 0.049; b = 26.1 ml/yr, Q = 0.032, respectively). Pathways and processes highlighted by our study include aberrant extracellular matrix remodeling, enhanced innate immune response, dysregulation of angiogenesis, and coagulation. Conclusions: In this study, we identify and validate novel biomarkers and pathways associated with lung function traits in a racially diverse population. In addition, we identify novel protein markers associated with FEV1 decline. Several protein findings are supported by previously reported genetic signals, highlighting the plausibility of certain biologic pathways. These novel proteins might represent markers for risk stratification, as well as novel molecular targets for treatment of COPD.
KW - airflow obstruction
KW - biomarkers
KW - proteomics
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UR - http://www.scopus.com/inward/citedby.url?scp=85167470634&partnerID=8YFLogxK
U2 - 10.1513/AnnalsATS.202210-857OC
DO - 10.1513/AnnalsATS.202210-857OC
M3 - Article
C2 - 37351609
AN - SCOPUS:85167470634
SN - 2325-6621
VL - 20
SP - 1124
EP - 1135
JO - Annals of the American Thoracic Society
JF - Annals of the American Thoracic Society
IS - 8
ER -