Systemic and uterine responsiveness to angiotensin II and norepinephrine in estrogen-treated nonpregnant sheep

Raymond P. Naden, Charles R. Rosenfeld

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Pregnancy is associated with uterine and systemic vasodilation and reduced vascular reactivity to angiotensin II and perhaps norepinephrine. The uteroplacental vasculature is relatively refractory to angiotensin II but very sensitive to norepinephrine. To investigate the possible role of the high levels of estrogen in pregnancy mediating these hemodynamic changes, we examined systemic and uterine vascular responsiveness to angiotensin II and norepinephrine in eight chronically instrumented nonpregnant sheep treated with 17β-estradiol. In these animals, 17β-estradiol produced significant systemic and uterine vasodilation without changing arterial pressure; cardiac output increased from 5.3 ± 0.3 to 6.7 ± 0.4 L/min, and uterine blood flow increased from 26 ± 3 to 218 ± 13 ml/min (mean ± SE). Treatment with 17β-estradiol reduced the increases in systemic vascular resistance produced by angiotensin II and norepinephrine by 25% and 35%, respectively. After 17β-estradiol treatment, the uterine vascular responses were compared to the systemic vascular responses; the uterine responses to angiotensin II were only half the systemic responses, whereas the uterine responses to norepinephrine were six times greater than the systemic responses and were associated with decreases in uterine blood flow of 35% to 40%. These hemodynamic features of nonpregnant sheep treated with estrogen are strikingly similar to previous observations in sheep during pregnancy.

Original languageEnglish (US)
Pages (from-to)417-425
Number of pages9
JournalAmerican journal of obstetrics and gynecology
Issue number4
StatePublished - Oct 15 1985


  • Uterine and systemic vascular responses
  • angiotensin II
  • estrogen-treated nonpregnant sheep
  • norepinephrine

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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