Synthetic Studies on the Kigamicins

Ai Jun Ma; Joseph M. Ready

doi:10.1021/acs.orglett.9b00098

Synthetic Studies on the Kigamicins

Ai Jun Ma, Joseph M. Ready

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The kigamicins are polycyclic aromatic natural products featuring a tetrahydroxanthone and up to four sugar residues. They are toxic to human cancer cells under nutrient-poor conditions. A synthesis of the natural product skeleton has been achieved from chiral pool materials. Key steps include a regioselective hydration of a diarylalkyne and two oxidative cyclizations.

Original language	English (US)
Pages (from-to)	1148-1151
Number of pages	4
Journal	Organic Letters
Volume	21
Issue number	4
DOIs	https://doi.org/10.1021/acs.orglett.9b00098
State	Published - Feb 15 2019

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/acs.orglett.9b00098

Cite this

@article{b1e1cef7f1404c89b503b7477aa1d931,

title = "Synthetic Studies on the Kigamicins",

abstract = "The kigamicins are polycyclic aromatic natural products featuring a tetrahydroxanthone and up to four sugar residues. They are toxic to human cancer cells under nutrient-poor conditions. A synthesis of the natural product skeleton has been achieved from chiral pool materials. Key steps include a regioselective hydration of a diarylalkyne and two oxidative cyclizations.",

author = "Ma, {Ai Jun} and Ready, {Joseph M.}",

note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = feb,

day = "15",

doi = "10.1021/acs.orglett.9b00098",

language = "English (US)",

volume = "21",

pages = "1148--1151",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "4",

}

TY - JOUR

T1 - Synthetic Studies on the Kigamicins

AU - Ma, Ai Jun

AU - Ready, Joseph M.

PY - 2019/2/15

Y1 - 2019/2/15

N2 - The kigamicins are polycyclic aromatic natural products featuring a tetrahydroxanthone and up to four sugar residues. They are toxic to human cancer cells under nutrient-poor conditions. A synthesis of the natural product skeleton has been achieved from chiral pool materials. Key steps include a regioselective hydration of a diarylalkyne and two oxidative cyclizations.

AB - The kigamicins are polycyclic aromatic natural products featuring a tetrahydroxanthone and up to four sugar residues. They are toxic to human cancer cells under nutrient-poor conditions. A synthesis of the natural product skeleton has been achieved from chiral pool materials. Key steps include a regioselective hydration of a diarylalkyne and two oxidative cyclizations.

UR - http://www.scopus.com/inward/record.url?scp=85061266237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061266237&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.9b00098

DO - 10.1021/acs.orglett.9b00098

M3 - Article

C2 - 30714741

AN - SCOPUS:85061266237

SN - 1523-7060

VL - 21

SP - 1148

EP - 1151

JO - Organic Letters

JF - Organic Letters

IS - 4

ER -

Synthetic Studies on the Kigamicins

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this