Synthesis of fluorescent polythiophene dots

Zhen Liu; Alaa Nahhas; Li Liu; Earl Ada; Xinyu Zhang; Sanjeev K. Manohar

doi:10.1155/2018/8987348

Synthesis of fluorescent polythiophene dots

Zhen Liu, Alaa Nahhas, Li Liu, Earl Ada, Xinyu Zhang, Sanjeev K. Manohar

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Abstract

Ring-functionalized semiconducting polythiophene dots (Pdots) were synthesized rapidly and in one step by the hydrazine hydrate reduction of doped parent polythiophene, obtained by conventional chemical oxidation of thiophene monomer by FeCl₃ in anhydrous acetonitrile. Dispersions of these Pdots display robust (pseudo) solvatochromism and solvatofluorism. Polythiophene Pdots exhibit significant cytotoxicity towards prostate cancer cells (expected) although when injected subcutaneously in vivo in live mouse, no toxicity is observed for 24 days when monitored in real time using fluorescence imaging.

Original language	English (US)
Article number	8987348
Journal	Journal of Nanomaterials
Volume	2018
DOIs	https://doi.org/10.1155/2018/8987348
State	Published - 2018

ASJC Scopus subject areas

Materials Science(all)

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title = "Synthesis of fluorescent polythiophene dots",

abstract = "Ring-functionalized semiconducting polythiophene dots (Pdots) were synthesized rapidly and in one step by the hydrazine hydrate reduction of doped parent polythiophene, obtained by conventional chemical oxidation of thiophene monomer by FeCl3 in anhydrous acetonitrile. Dispersions of these Pdots display robust (pseudo) solvatochromism and solvatofluorism. Polythiophene Pdots exhibit significant cytotoxicity towards prostate cancer cells (expected) although when injected subcutaneously in vivo in live mouse, no toxicity is observed for 24 days when monitored in real time using fluorescence imaging.",

author = "Zhen Liu and Alaa Nahhas and Li Liu and Earl Ada and Xinyu Zhang and Manohar, {Sanjeev K.}",

note = "Funding Information: The authors gratefully acknowledge financial support from Auburn University, the Robert and Gail Ward Endowed Professorship at the University of Massachusetts Lowell (UML), and the University of Texas Southwestern Medical Center. Publisher Copyright: {\textcopyright} 2018 Zhen Liu et al.",

year = "2018",

doi = "10.1155/2018/8987348",

language = "English (US)",

volume = "2018",

journal = "Journal of Nanomaterials",

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T1 - Synthesis of fluorescent polythiophene dots

AU - Liu, Zhen

AU - Nahhas, Alaa

AU - Liu, Li

AU - Ada, Earl

AU - Zhang, Xinyu

AU - Manohar, Sanjeev K.

N1 - Funding Information: The authors gratefully acknowledge financial support from Auburn University, the Robert and Gail Ward Endowed Professorship at the University of Massachusetts Lowell (UML), and the University of Texas Southwestern Medical Center. Publisher Copyright: © 2018 Zhen Liu et al.

PY - 2018

Y1 - 2018

N2 - Ring-functionalized semiconducting polythiophene dots (Pdots) were synthesized rapidly and in one step by the hydrazine hydrate reduction of doped parent polythiophene, obtained by conventional chemical oxidation of thiophene monomer by FeCl3 in anhydrous acetonitrile. Dispersions of these Pdots display robust (pseudo) solvatochromism and solvatofluorism. Polythiophene Pdots exhibit significant cytotoxicity towards prostate cancer cells (expected) although when injected subcutaneously in vivo in live mouse, no toxicity is observed for 24 days when monitored in real time using fluorescence imaging.

AB - Ring-functionalized semiconducting polythiophene dots (Pdots) were synthesized rapidly and in one step by the hydrazine hydrate reduction of doped parent polythiophene, obtained by conventional chemical oxidation of thiophene monomer by FeCl3 in anhydrous acetonitrile. Dispersions of these Pdots display robust (pseudo) solvatochromism and solvatofluorism. Polythiophene Pdots exhibit significant cytotoxicity towards prostate cancer cells (expected) although when injected subcutaneously in vivo in live mouse, no toxicity is observed for 24 days when monitored in real time using fluorescence imaging.

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Synthesis of fluorescent polythiophene dots

Abstract

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