Synthesis of an individualized cranial atlas with dysmorphic shape

Gary E. Christensen, Alex A. Kane, Jeffrey L. Marsh, Michael W. Vannier

Research output: Chapter in Book/Report/Conference proceedingConference contribution

18 Scopus citations


A new method for non-rigid registration of a normal infant CT head atlas with CT data of infants with abnormal skull shape is presented. An individualized atlas is synthesized by computing a volume transformation from the normal atlas to the target data set shape. This process begins rigidly by eliminating translation and rotation differences and proceeds non-rigidly to eliminate anatomical shape differences. Operator specified anatomical landmarks are used to find the initial rigid transformation. Non-rigid registration is achieved by constraining the transformation by the low frequency modes of vibration of a 3D linear-elastic solid while minimizing the squared intensity difference between atlas and target CT image volumes. Results are presented in which the CT atlas was transformed into the shape of several infants with various types of craniofacial deformities.

Original languageEnglish (US)
Title of host publicationProceedings of the Workship on Mathematical Methods in Biomedical Image Analysis
Editors Anon
Place of PublicationPiscataway, NJ, United States
Number of pages10
StatePublished - 1996
EventProceedings of the 1996 Workshop on Mathematical Methods in Biomedical Image Analysis - San Francisco, CA, USA
Duration: Jun 21 1996Jun 22 1996


OtherProceedings of the 1996 Workshop on Mathematical Methods in Biomedical Image Analysis
CitySan Francisco, CA, USA

ASJC Scopus subject areas

  • Engineering(all)

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