Synthesis of amines via coupling of imines and alkylarenes

Vaishnavi N. Nair, Uttam K. Tambar

Research output: Contribution to journalReview articlepeer-review


Recent advances in selective C[sbnd]H functionalization have resulted in powerful strategies for the synthesis of important target molecules from petroleum-derived hydrocarbons. In particular, alkylarenes such as toluene and xylenes are abundant feedstock chemicals that are emerging as useful substrates in C[sbnd]C and C[sbnd]X bond forming reactions. We review benzylic C[sbnd]H functionalization of alkylarenes for the synthesis of amines. We focus on the direct coupling of alkylarenes and imines through two distinct modes of activation: heterolytic and homolytic cleavage of benzylic C[sbnd]H bonds.

Original languageEnglish (US)
Article number153788
JournalTetrahedron Letters
StateAccepted/In press - 2022


  • Alkylarene
  • Amine
  • C[sbnd]H functionalization
  • Imine
  • Photochemistry
  • Radical

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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