Nitroalkanes bearing electron-withdrawing or unsaturated substituents at the α-carbon experience exclusive intra- and intermolecular 0-alkylation by alcohols under Mitsunobu condensation conditions furnishing good to excellent yields of alkyl nitronates; in contrast, 1-phenylsulphonyl-1-nitro-3-propanol affords mainly the corresponding cyclopropane.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Nov 3 1992|
- Nitronic ester
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry