Synthesis of alkyl nitronates via Mitsunobu condensation

J. R. Falck, Jurong Yu

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Nitroalkanes bearing electron-withdrawing or unsaturated substituents at the α-carbon experience exclusive intra- and intermolecular 0-alkylation by alcohols under Mitsunobu condensation conditions furnishing good to excellent yields of alkyl nitronates; in contrast, 1-phenylsulphonyl-1-nitro-3-propanol affords mainly the corresponding cyclopropane.

Original languageEnglish (US)
Pages (from-to)6723-6726
Number of pages4
JournalTetrahedron Letters
Issue number45
StatePublished - Nov 3 1992


  • 2-Isoxazoline-2-oxide
  • 5,6-dihydro-4H-oxazine-2-oxide
  • Mitsunobu
  • Nitronate
  • Nitronic ester

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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