Simple and efficient syntheses of 1233A analogs were developed and the inhibitory activity of the analogs against hydroxymethylglutaryl coenzyme A (HMG-CoA) synthase was determined. Study of the structure-activity relationships revealed that not only the geometry in β-lactone moiety but also the length of the carbon side chain is important for inhibitory activity against HMG-CoA synthase.
|Original language||English (US)|
|Number of pages||9|
|Journal||The Journal of Antibiotics|
|State||Published - 1992|
ASJC Scopus subject areas
- Drug Discovery