Synthesis and stereochemical assignment of FR252921, a promising immunosuppressant

J. Russell Falck; Anyu He; Hiroki Fukui; Hideyuki Tsutsui; Akella Radha

doi:10.1002/anie.200700321

Synthesis and stereochemical assignment of FR252921, a promising immunosuppressant

J. Russell Falck, Anyu He, Hiroki Fukui, Hideyuki Tsutsui, Akella Radha

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Synthetic detective work: FR252921, an unusual 19-membered lactone-dilactam, and three of its diastereomers were prepared by a versatile, convergent strategy from three key segments (see scheme). Comparison of the synthetic compounds with natural material established conclusively that FR252921 has the configuration 12S,13R,18R.

Original language	English (US)
Pages (from-to)	4527-4529
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	24
DOIs	https://doi.org/10.1002/anie.200700321
State	Published - 2007

Keywords

Configuration determination
Immunosuppressants
Macrocycles
Natural products
Total synthesis

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200700321

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abstract = "Synthetic detective work: FR252921, an unusual 19-membered lactone-dilactam, and three of its diastereomers were prepared by a versatile, convergent strategy from three key segments (see scheme). Comparison of the synthetic compounds with natural material established conclusively that FR252921 has the configuration 12S,13R,18R.",

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AU - He, Anyu

AU - Fukui, Hiroki

AU - Tsutsui, Hideyuki

AU - Radha, Akella

PY - 2007

Y1 - 2007

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KW - Configuration determination

KW - Immunosuppressants

KW - Macrocycles

KW - Natural products

KW - Total synthesis

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Synthesis and stereochemical assignment of FR252921, a promising immunosuppressant

Abstract

Keywords

ASJC Scopus subject areas

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