Synthesis and spectroscopy of near infrared fluorescent dyes for investigating dichromic fluorescence

Mingfeng Bai; Samuel Achilefu

doi:10.1016/j.bmcl.2010.11.024

Synthesis and spectroscopy of near infrared fluorescent dyes for investigating dichromic fluorescence

Mingfeng Bai, Samuel Achilefu

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We developed a series of near infrared (NIR) cyanine dyes to study dichromic fluorescence phenomenon, which provides new protocols for in vivo optical imaging. Preliminary spectroscopic studies show that dichromic fluorescence correlates with structural symmetry. This feature suggests the potential use of dichromic fluorescent molecules to study biological processes that can alter the structural symmetry of the molecular probes.

Original language	English (US)
Pages (from-to)	280-284
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2010.11.024
State	Published - Jan 1 2011
Externally published	Yes

Keywords

Contrast agent
Cyanine dye
Dual fluorescence
NIR
Optical imaging

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2010.11.024

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title = "Synthesis and spectroscopy of near infrared fluorescent dyes for investigating dichromic fluorescence",

abstract = "We developed a series of near infrared (NIR) cyanine dyes to study dichromic fluorescence phenomenon, which provides new protocols for in vivo optical imaging. Preliminary spectroscopic studies show that dichromic fluorescence correlates with structural symmetry. This feature suggests the potential use of dichromic fluorescent molecules to study biological processes that can alter the structural symmetry of the molecular probes.",

keywords = "Contrast agent, Cyanine dye, Dual fluorescence, NIR, Optical imaging",

author = "Mingfeng Bai and Samuel Achilefu",

note = "Funding Information: This work was supported in part by the US National Institutes of Health Grants NIBIB R01 EB00811 , R01 EB007276 , and NCI R33 CA123537 . ",

year = "2011",

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doi = "10.1016/j.bmcl.2010.11.024",

language = "English (US)",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Synthesis and spectroscopy of near infrared fluorescent dyes for investigating dichromic fluorescence

AU - Bai, Mingfeng

AU - Achilefu, Samuel

N1 - Funding Information: This work was supported in part by the US National Institutes of Health Grants NIBIB R01 EB00811 , R01 EB007276 , and NCI R33 CA123537 .

PY - 2011/1/1

Y1 - 2011/1/1

N2 - We developed a series of near infrared (NIR) cyanine dyes to study dichromic fluorescence phenomenon, which provides new protocols for in vivo optical imaging. Preliminary spectroscopic studies show that dichromic fluorescence correlates with structural symmetry. This feature suggests the potential use of dichromic fluorescent molecules to study biological processes that can alter the structural symmetry of the molecular probes.

AB - We developed a series of near infrared (NIR) cyanine dyes to study dichromic fluorescence phenomenon, which provides new protocols for in vivo optical imaging. Preliminary spectroscopic studies show that dichromic fluorescence correlates with structural symmetry. This feature suggests the potential use of dichromic fluorescent molecules to study biological processes that can alter the structural symmetry of the molecular probes.

KW - Contrast agent

KW - Cyanine dye

KW - Dual fluorescence

KW - NIR

KW - Optical imaging

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AN - SCOPUS:78650515861

SN - 0960-894X

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SP - 280

EP - 284

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

Synthesis and spectroscopy of near infrared fluorescent dyes for investigating dichromic fluorescence

Abstract

Keywords

ASJC Scopus subject areas

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