Synthesis and evaluation of polyhydroxylated near-infrared carbocyanine molecular probes

Zongren Zhang; Samuel Achilefu

doi:10.1021/ol049258a

Synthesis and evaluation of polyhydroxylated near-infrared carbocyanine molecular probes

Zongren Zhang, Samuel Achilefu

Research output: Contribution to journal › Article › peer-review

122 Scopus citations

Abstract

Equation presented. A new near-infrared (NIR) fluorescent molecular probe derived from indocarbocyanine dye and galactose was prepared, and the procedure was optimized. The presence of a nonionic polyhydroxyl moiety between hydrophobic groups enhances solubility and possibly minimizes aggregation in aqueous solutions. The structural framework of this molecule provides multivalent sites for labeling diverse molecules.

Original language	English (US)
Pages (from-to)	2067-2070
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	12
DOIs	https://doi.org/10.1021/ol049258a
State	Published - Jun 10 2004
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol049258a

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title = "Synthesis and evaluation of polyhydroxylated near-infrared carbocyanine molecular probes",

abstract = "Equation presented. A new near-infrared (NIR) fluorescent molecular probe derived from indocarbocyanine dye and galactose was prepared, and the procedure was optimized. The presence of a nonionic polyhydroxyl moiety between hydrophobic groups enhances solubility and possibly minimizes aggregation in aqueous solutions. The structural framework of this molecule provides multivalent sites for labeling diverse molecules.",

author = "Zongren Zhang and Samuel Achilefu",

year = "2004",

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doi = "10.1021/ol049258a",

language = "English (US)",

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AB - Equation presented. A new near-infrared (NIR) fluorescent molecular probe derived from indocarbocyanine dye and galactose was prepared, and the procedure was optimized. The presence of a nonionic polyhydroxyl moiety between hydrophobic groups enhances solubility and possibly minimizes aggregation in aqueous solutions. The structural framework of this molecule provides multivalent sites for labeling diverse molecules.

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JO - Organic Letters

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Synthesis and evaluation of polyhydroxylated near-infrared carbocyanine molecular probes

Abstract

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