Synthesis and characterization of some cobalt (II) complexes with amino acids having biological activities

Dan Rusu, Andreea Stanila, Iliu Ovidiu Marian, Calin Ovidiu Marian, Mariana Rusu, Roxana Lucaciu

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17 Scopus citations


Cobalt-amino acids complexes in aqueous solution: [Co-(L H 1O)2]×H2O (1), (L1=lysine), [Co- (L2H2O)J×.H2O (2), (L 2=Ieucine) and [Co(L3H2O)]×2H 2O (3), (L3=methionine) were synthesized and characterized by means of elemental, thermal ana IR, UV-VIS, and EPR spectroscopic investigations, and biological measurements. The IR spectra show that amino acids act as bidentate ligands with coordination involving the carboxylic oxygen and the nitrogen atom of the amino group. The v(C=O), v(N-H), and 5(N- H) vibrations are shifted toward higher frequencies for complexes comparable with ligands. Visible electronic and powder EPR spectres at room temperature are typical for monomeric species with octahedric local symmetry around the metal ion. The biological testing of the synthesized complexes was done to see citotoxic activity that might show on cell cultures of Sacharomices cerevisiae and Candida albicans.

Original languageEnglish (US)
Pages (from-to)939-943
Number of pages5
JournalRevista de Chimie
Issue number9
StatePublished - Sep 2009


  • Amino acids
  • Biological testing
  • Co(II) complexes
  • FT-IR/UV-VIS/EPR spectroscopy

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Chemistry(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Materials Science (miscellaneous)


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