Synthesis and characterization of some cobalt (II) complexes with amino acids having biological activities

Dan Rusu; Andreea Stanila; Iliu Ovidiu Marian; Calin Ovidiu Marian; Mariana Rusu; Roxana Lucaciu

Synthesis and characterization of some cobalt (II) complexes with amino acids having biological activities

Dan Rusu, Andreea Stanila, Iliu Ovidiu Marian, Calin Ovidiu Marian, Mariana Rusu, Roxana Lucaciu

Urology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Cobalt-amino acids complexes in aqueous solution: [Co-(L H ₁O)₂]×H₂O (1), (L₁=lysine), [Co- (L₂H₂O)J×.H₂O (2), (L ₂=Ieucine) and [Co(L₃H₂O)]×2H ₂O (3), (L₃=methionine) were synthesized and characterized by means of elemental, thermal ana IR, UV-VIS, and EPR spectroscopic investigations, and biological measurements. The IR spectra show that amino acids act as bidentate ligands with coordination involving the carboxylic oxygen and the nitrogen atom of the amino group. The v(C=O), v(N-H), and 5(N- H) vibrations are shifted toward higher frequencies for complexes comparable with ligands. Visible electronic and powder EPR spectres at room temperature are typical for monomeric species with octahedric local symmetry around the metal ion. The biological testing of the synthesized complexes was done to see citotoxic activity that might show on cell cultures of Sacharomices cerevisiae and Candida albicans.

Original language	English (US)
Pages (from-to)	939-943
Number of pages	5
Journal	Revista de Chimie
Volume	60
Issue number	9
State	Published - Sep 2009

Keywords

Amino acids
Biological testing
Co(II) complexes
FT-IR/UV-VIS/EPR spectroscopy

ASJC Scopus subject areas

Engineering(all)
Materials Chemistry
Surfaces, Coatings and Films
Chemistry(all)
Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)
Materials Science (miscellaneous)

Cite this

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title = "Synthesis and characterization of some cobalt (II) complexes with amino acids having biological activities",

abstract = "Cobalt-amino acids complexes in aqueous solution: [Co-(L H 1O)2]×H2O (1), (L1=lysine), [Co- (L2H2O)J×.H2O (2), (L 2=Ieucine) and [Co(L3H2O)]×2H 2O (3), (L3=methionine) were synthesized and characterized by means of elemental, thermal ana IR, UV-VIS, and EPR spectroscopic investigations, and biological measurements. The IR spectra show that amino acids act as bidentate ligands with coordination involving the carboxylic oxygen and the nitrogen atom of the amino group. The v(C=O), v(N-H), and 5(N- H) vibrations are shifted toward higher frequencies for complexes comparable with ligands. Visible electronic and powder EPR spectres at room temperature are typical for monomeric species with octahedric local symmetry around the metal ion. The biological testing of the synthesized complexes was done to see citotoxic activity that might show on cell cultures of Sacharomices cerevisiae and Candida albicans.",

keywords = "Amino acids, Biological testing, Co(II) complexes, FT-IR/UV-VIS/EPR spectroscopy",

author = "Dan Rusu and Andreea Stanila and Marian, {Iliu Ovidiu} and Marian, {Calin Ovidiu} and Mariana Rusu and Roxana Lucaciu",

year = "2009",

month = sep,

language = "English (US)",

volume = "60",

pages = "939--943",

journal = "Revista de Chimie",

issn = "0034-7752",

publisher = "Syscom 18 SRL",

number = "9",

}

TY - JOUR

T1 - Synthesis and characterization of some cobalt (II) complexes with amino acids having biological activities

AU - Rusu, Dan

AU - Stanila, Andreea

AU - Marian, Iliu Ovidiu

AU - Marian, Calin Ovidiu

AU - Rusu, Mariana

AU - Lucaciu, Roxana

PY - 2009/9

Y1 - 2009/9

N2 - Cobalt-amino acids complexes in aqueous solution: [Co-(L H 1O)2]×H2O (1), (L1=lysine), [Co- (L2H2O)J×.H2O (2), (L 2=Ieucine) and [Co(L3H2O)]×2H 2O (3), (L3=methionine) were synthesized and characterized by means of elemental, thermal ana IR, UV-VIS, and EPR spectroscopic investigations, and biological measurements. The IR spectra show that amino acids act as bidentate ligands with coordination involving the carboxylic oxygen and the nitrogen atom of the amino group. The v(C=O), v(N-H), and 5(N- H) vibrations are shifted toward higher frequencies for complexes comparable with ligands. Visible electronic and powder EPR spectres at room temperature are typical for monomeric species with octahedric local symmetry around the metal ion. The biological testing of the synthesized complexes was done to see citotoxic activity that might show on cell cultures of Sacharomices cerevisiae and Candida albicans.

AB - Cobalt-amino acids complexes in aqueous solution: [Co-(L H 1O)2]×H2O (1), (L1=lysine), [Co- (L2H2O)J×.H2O (2), (L 2=Ieucine) and [Co(L3H2O)]×2H 2O (3), (L3=methionine) were synthesized and characterized by means of elemental, thermal ana IR, UV-VIS, and EPR spectroscopic investigations, and biological measurements. The IR spectra show that amino acids act as bidentate ligands with coordination involving the carboxylic oxygen and the nitrogen atom of the amino group. The v(C=O), v(N-H), and 5(N- H) vibrations are shifted toward higher frequencies for complexes comparable with ligands. Visible electronic and powder EPR spectres at room temperature are typical for monomeric species with octahedric local symmetry around the metal ion. The biological testing of the synthesized complexes was done to see citotoxic activity that might show on cell cultures of Sacharomices cerevisiae and Candida albicans.

KW - Amino acids

KW - Biological testing

KW - Co(II) complexes

KW - FT-IR/UV-VIS/EPR spectroscopy

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M3 - Article

AN - SCOPUS:71049169689

SN - 0034-7752

VL - 60

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JO - Revista de Chimie

JF - Revista de Chimie

IS - 9

ER -

Synthesis and characterization of some cobalt (II) complexes with amino acids having biological activities

Abstract

Keywords

ASJC Scopus subject areas

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