TY - JOUR
T1 - Syngeneic renal transplantation increases the number of renal dendritic cells in the rat
AU - Penfield, Jeffrey G.
AU - Dawidson, Ingemar A.
AU - Ar'Rajab, Aamer
AU - Kielar, Mariusz A.
AU - Jeyarajah, D. Rohan
AU - Lu, Christopher Y.
N1 - Funding Information:
CY Lu was supported by grants from the American Heart Association, and NIH grant RO1-DK54304. M Kielar and J Penfield were supported by a NIH Institutional National Research Service Award to the Division of Nephrology, University of Texas Southwestern Medical School (2T32-DK07257-11A2). J Penfield is supported by a Fellowship Grant from the National Kidney Foundation. Drs Jeyarajah and Kielar are also supported by a grant from the American Heart Association. The authors are grateful for the excellent technical support of Ms Linda Che and Mr Jim Sentimentes.
PY - 1999/12
Y1 - 1999/12
N2 - Dendritic cells participate in the regulation of CD4 and CD8 T cells during transplant rejection. Understanding what causes increased numbers of dendritic cells to appear in the renal transplant is therefore important. We performed syngeneic renal transplants between rats. We used the monoclonal antibody OX62 to detect dendritic cells, and OX6 to detect major histocompatability complex (MHC) Class II in the renal transplant. One week after transplant, dendritic cells appeared. This indicates that the injury of transplantation itself is sufficient to increase the number of dendritic cells in the kidney in a model where there is no alloreactivity.
AB - Dendritic cells participate in the regulation of CD4 and CD8 T cells during transplant rejection. Understanding what causes increased numbers of dendritic cells to appear in the renal transplant is therefore important. We performed syngeneic renal transplants between rats. We used the monoclonal antibody OX62 to detect dendritic cells, and OX6 to detect major histocompatability complex (MHC) Class II in the renal transplant. One week after transplant, dendritic cells appeared. This indicates that the injury of transplantation itself is sufficient to increase the number of dendritic cells in the kidney in a model where there is no alloreactivity.
UR - http://www.scopus.com/inward/record.url?scp=0033402039&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033402039&partnerID=8YFLogxK
U2 - 10.1016/S0966-3274(99)80002-1
DO - 10.1016/S0966-3274(99)80002-1
M3 - Article
C2 - 10638831
AN - SCOPUS:0033402039
SN - 0966-3274
VL - 7
SP - 197
EP - 200
JO - Transplant Immunology
JF - Transplant Immunology
IS - 4
ER -