TY - JOUR
T1 - Synchrony drives motor cortex beta bursting,waveform dynamics, and phase-amplitude coupling in parkinson's disease
AU - O'Keeffe, Andrew B.
AU - Malekmohammadi, Mahsa
AU - Sparks, Hiro
AU - Pouratian, Nader
N1 - Publisher Copyright:
© 2020 Society for Neuroscience. All rights reserved.
PY - 2020/7/22
Y1 - 2020/7/22
N2 - Several lines of inquiry have separately identified beta oscillations, synchrony, waveform shape, and phase-amplitude coupling as important but sometimes inconsistent factors in the pathophysiology of Parkinson's disease. What has so far been lacking is a means by which these neurophysiological parameters are interrelated and how they relate to clinical symptomatology. To clarify the relationship among oscillatory power, bursting, synchrony, and phase-amplitude coupling, we recorded local field potentials/electrocorticography from hand motor and premotor cortical area in human subjects with c (N= 10) and Parkinson's disease (N= 22) during deep brain stimulator implantation surgery (14 females, 18 males). We show that motor cortical high beta oscillations in Parkinson's disease demonstrate increased burst durations relative to essential tremor patients. Notably, increased corticocortical synchrony between primary motor and premotor cortices precedes motor high beta bursts, suggesting a possible causal relationship between corticocortical synchrony and localized increases in beta power. We further show that high beta bursts are associated with significant changes in waveform shape and that beta-encoded phase-amplitude coupling is more evident during periods of high beta bursting. These findings reveal a deeper structure to the pathologic changes identified in the neurophysiology of Parkinson's disease, suggesting mechanisms by which the treatment may be enhanced using targeted network synchrony disruption approaches.
AB - Several lines of inquiry have separately identified beta oscillations, synchrony, waveform shape, and phase-amplitude coupling as important but sometimes inconsistent factors in the pathophysiology of Parkinson's disease. What has so far been lacking is a means by which these neurophysiological parameters are interrelated and how they relate to clinical symptomatology. To clarify the relationship among oscillatory power, bursting, synchrony, and phase-amplitude coupling, we recorded local field potentials/electrocorticography from hand motor and premotor cortical area in human subjects with c (N= 10) and Parkinson's disease (N= 22) during deep brain stimulator implantation surgery (14 females, 18 males). We show that motor cortical high beta oscillations in Parkinson's disease demonstrate increased burst durations relative to essential tremor patients. Notably, increased corticocortical synchrony between primary motor and premotor cortices precedes motor high beta bursts, suggesting a possible causal relationship between corticocortical synchrony and localized increases in beta power. We further show that high beta bursts are associated with significant changes in waveform shape and that beta-encoded phase-amplitude coupling is more evident during periods of high beta bursting. These findings reveal a deeper structure to the pathologic changes identified in the neurophysiology of Parkinson's disease, suggesting mechanisms by which the treatment may be enhanced using targeted network synchrony disruption approaches.
KW - Deep Brain Stimulation
KW - Electrocorticography
KW - Motor Cortex
KW - Phase Amplitude Coupling
KW - Synchrony
KW - Waveform Analysis
UR - http://www.scopus.com/inward/record.url?scp=85088490592&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85088490592&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.1996-19.2020
DO - 10.1523/JNEUROSCI.1996-19.2020
M3 - Article
C2 - 32576623
AN - SCOPUS:85088490592
SN - 0270-6474
VL - 40
SP - 5833
EP - 5846
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 30
ER -