Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling

Tuhin Virmani, Weiping Han, Xinran Liu, Thomas C. Südhof, Ege T. Kavalali

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


The speed of synaptic vesicle recycling determines the efficacy of neurotransmission during repetitive stimulation. Synaptotagmins are synaptic C2-domain proteins that are involved in exocytosis, but have also been linked to endocytosis. We now demonstrate that upon expression in transfected neurons, a short splice variant of synaptotagmin 7 that lacks C 2-domains accelerates endocytic recycling of synaptic vesicles, whereas a longer splice variant that contains C2-domains decelerates recycling. These results suggest that alternative splicing of synaptotagmin 7 acts as a molecular switch, which targets vesicles to fast and slow recycling pathways.

Original languageEnglish (US)
Pages (from-to)5347-5357
Number of pages11
JournalEMBO Journal
Issue number20
StatePublished - Oct 15 2003


  • FM1-43
  • Hippocampal synapse
  • Kiss and run
  • Synaptic vesicle recycling
  • Synaptotagmin 7

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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