TY - JOUR
T1 - Synaptic vesicle fusion
AU - Rizo-Rey, Jose
AU - Rosenmund, Christian
N1 - Funding Information:
Work in the authors’ laboratories is supported by US National Institutes of Health grants NS40944 and NS37200 (to J.R.) and NS050655 and NS051262 (to C.R.).
PY - 2008/7
Y1 - 2008/7
N2 - The core of the neurotransmitter release machinery is formed by SNARE complexes, which bring the vesicle and plasma membranes together and are key for fusion, and by Munc18-1, which controls SNARE-complex formation and may also have a direct role in fusion. In addition, SNARE complex assembly is likely orchestrated by Munc13s and RIMs, active-zone proteins that function in vesicle priming and diverse forms of presynaptic plasticity. Synaptotagmin-1 mediates triggering of release by Ca2+, probably through interactions with SNAREs and both membranes, as well as through a tight interplay with complexins. Elucidation of the release mechanism will require a full understanding of the network of interactions among all these proteins and the membranes.
AB - The core of the neurotransmitter release machinery is formed by SNARE complexes, which bring the vesicle and plasma membranes together and are key for fusion, and by Munc18-1, which controls SNARE-complex formation and may also have a direct role in fusion. In addition, SNARE complex assembly is likely orchestrated by Munc13s and RIMs, active-zone proteins that function in vesicle priming and diverse forms of presynaptic plasticity. Synaptotagmin-1 mediates triggering of release by Ca2+, probably through interactions with SNAREs and both membranes, as well as through a tight interplay with complexins. Elucidation of the release mechanism will require a full understanding of the network of interactions among all these proteins and the membranes.
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U2 - 10.1038/nsmb.1450
DO - 10.1038/nsmb.1450
M3 - Review article
C2 - 18618940
AN - SCOPUS:46449137569
SN - 1545-9993
VL - 15
SP - 665
EP - 674
JO - Nature Structural and Molecular Biology
JF - Nature Structural and Molecular Biology
IS - 7
ER -