Switch-like Transitions Insulate Network Motifs to Modularize Biological Networks

Oguzhan Atay, Andreas Doncic, Jan M. Skotheim

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Cellular decisions are made by complex networks that are difficult to analyze. Although it is common to analyze smaller sub-networks known as network motifs, it is unclear whether this is valid, because these motifs are embedded in complex larger networks. Here, we address the general question of modularity by examining the S. cerevisiae pheromone response. We demonstrate that the feedforward motif controlling the cell-cycle inhibitor Far1 is insulated from cell-cycle dynamics by the positive feedback switch that drives reentry to the cell cycle. Before cells switch on positive feedback, the feedforward motif model predicts the behavior of the larger network. Conversely, after the switch, the feedforward motif is dismantled and has no discernable effect on the cell cycle. When insulation is broken, the feedforward motif no longer predicts network behavior. This work illustrates how, despite the interconnectivity of networks, the activity of motifs can be insulated by switches that generate well-defined cellular states.

Original languageEnglish (US)
Pages (from-to)121-132
Number of pages12
JournalCell Systems
Issue number2
StatePublished - Aug 24 2016

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology


Dive into the research topics of 'Switch-like Transitions Insulate Network Motifs to Modularize Biological Networks'. Together they form a unique fingerprint.

Cite this