Surgical site infections after colorectal surgery: Do risk factors vary depending on the type of infection considered?

Jennifer Blumetti, Myda Luu, George Sarosi, Kathleen Hartless, Jackie McFarlin, Betty Parker, Sean Dineen, Sergio Huerta, Massimo Asolati, Esteban Varela, Thomas Anthony

Research output: Contribution to journalArticlepeer-review

130 Scopus citations


Background: The purpose of this study was to compare risk factors for the development of incisional versus organ/space infections in patients undergoing colorectal surgery. Methods: An institutional review board-approved retrospective review was performed examining a 4-year period (January 2002 to December 2005). Patients were included if they had undergone abdominal operations (open or laparoscopic) in which the colon/rectum was surgically manipulated. Patients were excluded if the surgical wound was not closed primarily. A standardized definition of incisional and organ/space infection was employed. Results: A total of 428 operations were performed. Overall, 105 infections were identified (25%); 73 involved the incision and 32 were classified as organ/space. Multivariate analysis suggested that incisional infection was independently associated with body mass index (odds ratio [OR], 1.07; 95% confidence interval [CI], 1.02-1.11) and creation/revision/reversal of an ostomy (OR, 2.2; 95% CI, 1.3-3.9). Organ/space infection was independently associated with perioperative transfusion (OR, 2.3; 95% CI, 1.1-5.5) and with previous abdominal surgery (OR, 2.5; 95% CI, 1.2-5.3). Conclusions: Factors associated with infection differed based on the type of surgical site infection being considered. The lack of overlap between factors associated with incisional infection and organ/space infection suggests that separate risk models and treatment strategies should be developed.

Original languageEnglish (US)
Pages (from-to)704-711
Number of pages8
Issue number5
StatePublished - Nov 1 2007

ASJC Scopus subject areas

  • Surgery


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