The use of an albumin-gamma-globulin complex coating to solve the host-defense problems of foreign materials used in blood-contacting devices is under investigation. The approach that is described here is based on the discovery of a method to bind this serum protein to a number of polymer surfaces stably and conveniently. The method appears to have some practical advantages, and it utilizes a model that is useful for studying biological mechanisms for the organization of the blood-polymer interface. The development of this method and some biological results are described.
|Number of pages
|IEEE Engineering in Medicine and Biology Magazine
|Published - Jun 1 1989
ASJC Scopus subject areas
- Biomedical Engineering