Abstract
Peritoneal dialysis-associated peritonitis from such resistant organisms as vancomycin-resistant enterococci increasingly is occurring and is challenging to treat. We describe 2 cases of vancomycin-resistant entercoccus peritonitis successfully treated with intraperitoneal daptomycin. Both patients were on automated peritoneal dialysis therapy with culture-positive vancomycin-resistant Enterococcus faecium peritonitis and were treated with 10 to 14 days of intraperitoneal daptomycin given every 4 hours through manual peritoneal dialysate exchanges. Despite the known degradation in dextrose solutions, intraperitoneal daptomycin was effective in clearing both infections. Neither patient experienced a relapse or repeated peritonitis. Additional studies of dosing and pharmacokinetics of intraperitoneal daptomycin in the treatment of patients with vancomycin-resistant enterococcus peritonitis are needed.
Original language | English (US) |
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Pages (from-to) | 538-541 |
Number of pages | 4 |
Journal | American Journal of Kidney Diseases |
Volume | 54 |
Issue number | 3 |
DOIs | |
State | Published - Sep 1 2009 |
Keywords
- Peritoneal dialysis
- daptomycin
- peritonitis
- vancomycin-resistant enterococcus
ASJC Scopus subject areas
- Nephrology