Abstract
We report our clinical experience treating a 2-month-old infant with congenital diaphragmatic hernia who experienced prolonged bacteremia with Burkholderia cepacia complex (Bcc) despite conventional antibiotic therapy and appropriate source control measures. The infection resolved after initiation of ceftazidime-avibactam. Wholegenome sequencing revealed that the isolate most closely resembled B. contaminans and identified the mechanism of resistance that likely contributed to clinical cure with this agent. Ceftazidime-avibactam should be considered salvage therapy for Bcc infections if other treatment options have been exhausted.
Original language | English (US) |
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Article number | e02213-17 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 62 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2018 |
Keywords
- Bacteremia
- Burkholderia cepacia complex
- Ceftazidime-avibactam
- Whole-genome sequencing
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases