Studying Lineage Plasticity One Cell at a Time

Benjamin J. Drapkin; John D. Minna

doi:10.1016/j.ccell.2020.07.001

Studying Lineage Plasticity One Cell at a Time

Benjamin J. Drapkin, John D. Minna

Research output: Contribution to journal › Comment/debate › peer-review

7 Scopus citations

Abstract

The development and consequences of lineage plasticity during tumorigenesis have remained mysterious due to the limits of single-cell analysis. In this issue of Cancer Cell, LaFave et al. and Marjanovic et al. identify highly plastic subpopulations within lung adenocarcinoma that may underlie intratumoral lineage heterogeneity, metastasis, and acquired resistance to chemotherapy.

Original language	English (US)
Pages (from-to)	150-152
Number of pages	3
Journal	Cancer Cell
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/j.ccell.2020.07.001
State	Published - Aug 10 2020

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.ccell.2020.07.001

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title = "Studying Lineage Plasticity One Cell at a Time",

abstract = "The development and consequences of lineage plasticity during tumorigenesis have remained mysterious due to the limits of single-cell analysis. In this issue of Cancer Cell, LaFave et al. and Marjanovic et al. identify highly plastic subpopulations within lung adenocarcinoma that may underlie intratumoral lineage heterogeneity, metastasis, and acquired resistance to chemotherapy.",

author = "Drapkin, {Benjamin J.} and Minna, {John D.}",

note = "Funding Information: Supported by NCI SPORE in Lung Cancer P50CA070907 and the CPRIT First-Time Investigator Award RR200007. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

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doi = "10.1016/j.ccell.2020.07.001",

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AU - Minna, John D.

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N2 - The development and consequences of lineage plasticity during tumorigenesis have remained mysterious due to the limits of single-cell analysis. In this issue of Cancer Cell, LaFave et al. and Marjanovic et al. identify highly plastic subpopulations within lung adenocarcinoma that may underlie intratumoral lineage heterogeneity, metastasis, and acquired resistance to chemotherapy.

AB - The development and consequences of lineage plasticity during tumorigenesis have remained mysterious due to the limits of single-cell analysis. In this issue of Cancer Cell, LaFave et al. and Marjanovic et al. identify highly plastic subpopulations within lung adenocarcinoma that may underlie intratumoral lineage heterogeneity, metastasis, and acquired resistance to chemotherapy.

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VL - 38

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JO - Cancer Cell

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Studying Lineage Plasticity One Cell at a Time

Abstract

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