Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo

Jonathan M. Graff; R. Scott Thies; Jeffrey J. Song; Anthony J. Celeste; Douglas A. Melton

doi:10.1016/0092-8674(94)90409-X

Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo

Jonathan M. Graff, R. Scott Thies, Jeffrey J. Song, Anthony J. Celeste, Douglas A. Melton

Research output: Contribution to journal › Article › peer-review

430 Scopus citations

Abstract

We report the isolation of a Xenopus BMP receptor that is expressed maternally in the appropriate location to play a role in mesoderm induction. This receptor binds both BMP-2 and BMP-4 with high affinity. A truncated form of this BMP receptor specifically blocks BMP-4 signaling. Expression of this truncated BMP receptor during embryogenesis converts ventral mesoderm to dorsal mesoderm. Contrary to the popularly held view that ventral is the ground state for all mesoderm, our results suggest that formation of ventral mesoderm requires an active signal and that, in the absence of this ventral signal, dorsal mesoderm is formed.

Original language	English (US)
Pages (from-to)	169-179
Number of pages	11
Journal	Cell
Volume	79
Issue number	1
DOIs	https://doi.org/10.1016/0092-8674(94)90409-X
State	Published - Oct 7 1994

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/0092-8674(94)90409-X

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title = "Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo",

abstract = "We report the isolation of a Xenopus BMP receptor that is expressed maternally in the appropriate location to play a role in mesoderm induction. This receptor binds both BMP-2 and BMP-4 with high affinity. A truncated form of this BMP receptor specifically blocks BMP-4 signaling. Expression of this truncated BMP receptor during embryogenesis converts ventral mesoderm to dorsal mesoderm. Contrary to the popularly held view that ventral is the ground state for all mesoderm, our results suggest that formation of ventral mesoderm requires an active signal and that, in the absence of this ventral signal, dorsal mesoderm is formed.",

author = "Graff, {Jonathan M.} and Thies, {R. Scott} and Song, {Jeffrey J.} and Celeste, {Anthony J.} and Melton, {Douglas A.}",

note = "Funding Information: We want to thank Anu Bansal, lman Brivanlou, Cord Dohrman, David Gifford, Ali Hemmati-Brivanlou, Elaine Joseph, Olivia Kelly, Dan Kes-sler, Peter Klein, Stephanie Kong, Min Ku, Yi Rao, Karlyne Reilly, George Serbeclzija, Marc Wathelet, Paul Wilson, and John Wozney. J. G. is a Howard Hughes Medical Institute Physcian Research Fellow. This work was supported by a grant from the National Institutes of Health to D. M.",

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doi = "10.1016/0092-8674(94)90409-X",

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AU - Graff, Jonathan M.

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AU - Celeste, Anthony J.

AU - Melton, Douglas A.

N1 - Funding Information: We want to thank Anu Bansal, lman Brivanlou, Cord Dohrman, David Gifford, Ali Hemmati-Brivanlou, Elaine Joseph, Olivia Kelly, Dan Kes-sler, Peter Klein, Stephanie Kong, Min Ku, Yi Rao, Karlyne Reilly, George Serbeclzija, Marc Wathelet, Paul Wilson, and John Wozney. J. G. is a Howard Hughes Medical Institute Physcian Research Fellow. This work was supported by a grant from the National Institutes of Health to D. M.

PY - 1994/10/7

Y1 - 1994/10/7

N2 - We report the isolation of a Xenopus BMP receptor that is expressed maternally in the appropriate location to play a role in mesoderm induction. This receptor binds both BMP-2 and BMP-4 with high affinity. A truncated form of this BMP receptor specifically blocks BMP-4 signaling. Expression of this truncated BMP receptor during embryogenesis converts ventral mesoderm to dorsal mesoderm. Contrary to the popularly held view that ventral is the ground state for all mesoderm, our results suggest that formation of ventral mesoderm requires an active signal and that, in the absence of this ventral signal, dorsal mesoderm is formed.

AB - We report the isolation of a Xenopus BMP receptor that is expressed maternally in the appropriate location to play a role in mesoderm induction. This receptor binds both BMP-2 and BMP-4 with high affinity. A truncated form of this BMP receptor specifically blocks BMP-4 signaling. Expression of this truncated BMP receptor during embryogenesis converts ventral mesoderm to dorsal mesoderm. Contrary to the popularly held view that ventral is the ground state for all mesoderm, our results suggest that formation of ventral mesoderm requires an active signal and that, in the absence of this ventral signal, dorsal mesoderm is formed.

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Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo

Abstract

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