Studies on the relationship between HLA DR4 and in vitro IgM rheumatoid factor production

Martin A. Rodriguez; Arthur D. Bankhurst; Ralph C. Williams; Gary M. Troup; Peter Stastny

doi:10.1016/0090-1229(83)90059-4

Studies on the relationship between HLA DR4 and in vitro IgM rheumatoid factor production

Martin A. Rodriguez, Arthur D. Bankhurst, Ralph C. Williams, Gary M. Troup, Peter Stastny

Internal Medicine

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The relationship between the presence of the DR4 antigen and other HLA antigens and in vitro production of IgM-rheumatoid factor by lymphocytes from a group of healthy young subjects was examined. Pokeweed and Epstein-Barr virus-stimulated lymphocyte cultures were examined for the production of rheumatoid factor and immunoglobulins. No significant correlation was found between the presence of the DR4 antigen and in vitro production of IgM rheumatoid factor. The presence of the B18 antigen seemed to identify a population of nonresponders when stimulated with PWM.

Original language	English (US)
Pages (from-to)	96-109
Number of pages	14
Journal	Clinical Immunology and Immunopathology
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/0090-1229(83)90059-4
State	Published - Apr 1983

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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title = "Studies on the relationship between HLA DR4 and in vitro IgM rheumatoid factor production",

abstract = "The relationship between the presence of the DR4 antigen and other HLA antigens and in vitro production of IgM-rheumatoid factor by lymphocytes from a group of healthy young subjects was examined. Pokeweed and Epstein-Barr virus-stimulated lymphocyte cultures were examined for the production of rheumatoid factor and immunoglobulins. No significant correlation was found between the presence of the DR4 antigen and in vitro production of IgM rheumatoid factor. The presence of the B18 antigen seemed to identify a population of nonresponders when stimulated with PWM.",

author = "Rodriguez, {Martin A.} and Bankhurst, {Arthur D.} and Williams, {Ralph C.} and Troup, {Gary M.} and Peter Stastny",

note = "Funding Information: I Supported by NIH Grants AMAI13690-14 and AMA113824-12, and CA-24870-04. ? Dr. Rodriguez supported in part by grants from Fundacion “&an Mar&al de Ayacucho Centro National de Enfermedades Reumaticas MSAS, Caracas, Venezuela. s Abbreviations used: RF, rheumatoid factor: RA, rheumatoid arthritis: Ig. immunoglobulin: Epstein-Barr virus: PWM, pokeweed mitogen; FCS, fetal calf serum.",

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doi = "10.1016/0090-1229(83)90059-4",

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T1 - Studies on the relationship between HLA DR4 and in vitro IgM rheumatoid factor production

AU - Rodriguez, Martin A.

AU - Bankhurst, Arthur D.

AU - Williams, Ralph C.

AU - Troup, Gary M.

AU - Stastny, Peter

N1 - Funding Information: I Supported by NIH Grants AMAI13690-14 and AMA113824-12, and CA-24870-04. ? Dr. Rodriguez supported in part by grants from Fundacion “&an Mar&al de Ayacucho Centro National de Enfermedades Reumaticas MSAS, Caracas, Venezuela. s Abbreviations used: RF, rheumatoid factor: RA, rheumatoid arthritis: Ig. immunoglobulin: Epstein-Barr virus: PWM, pokeweed mitogen; FCS, fetal calf serum.

PY - 1983/4

Y1 - 1983/4

N2 - The relationship between the presence of the DR4 antigen and other HLA antigens and in vitro production of IgM-rheumatoid factor by lymphocytes from a group of healthy young subjects was examined. Pokeweed and Epstein-Barr virus-stimulated lymphocyte cultures were examined for the production of rheumatoid factor and immunoglobulins. No significant correlation was found between the presence of the DR4 antigen and in vitro production of IgM rheumatoid factor. The presence of the B18 antigen seemed to identify a population of nonresponders when stimulated with PWM.

AB - The relationship between the presence of the DR4 antigen and other HLA antigens and in vitro production of IgM-rheumatoid factor by lymphocytes from a group of healthy young subjects was examined. Pokeweed and Epstein-Barr virus-stimulated lymphocyte cultures were examined for the production of rheumatoid factor and immunoglobulins. No significant correlation was found between the presence of the DR4 antigen and in vitro production of IgM rheumatoid factor. The presence of the B18 antigen seemed to identify a population of nonresponders when stimulated with PWM.

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Studies on the relationship between HLA DR4 and in vitro IgM rheumatoid factor production

Abstract

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