TY - JOUR
T1 - Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway
AU - Zhang, Xuewu
AU - Bai, Xiao chen
AU - Chen, Zhijian J.
N1 - Funding Information:
Work in our laboratories has been supported by grants from the National Institutes of Health ( U54CA244719 to Z.J.C., R35GM130289 to X.Z., and R01GM136976 to X.-c.B.), the Welch Foundation ( I-1389 to Z.J.C., I-1702 to X.Z., and I-1944 to X.-c.B.), and the Cancer Prevention and Research Institute of Texas ( RP180725 to Z.J.C. and RP16082 to X.-c.B.). Z.J.C. is an investigator of the Howard Hughes Medical Institute .
Funding Information:
Work in our laboratories has been supported by grants from the National Institutes of Health (U54CA244719 to Z.J.C. R35GM130289 to X.Z. and R01GM136976 to X.-c.B.), the Welch Foundation (I-1389 to Z.J.C. I-1702 to X.Z. and I-1944 to X.-c.B.), and the Cancer Prevention and Research Institute of Texas (RP180725 to Z.J.C. and RP16082 to X.-c.B.). Z.J.C. is an investigator of the Howard Hughes Medical Institute.
Publisher Copyright:
© 2020
PY - 2020/7/14
Y1 - 2020/7/14
N2 - Besides its role as the blueprint of life, DNA can also alert the cell to the presence of microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that triggers the innate immune response is cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase (cGAS), which produces the second messenger cGAMP. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators. Recent research has demonstrated an expanding role of the cGAS-cGAMP-STING pathway in many physiological and pathological processes, including host defense against microbial infections, anti-tumor immunity, cellular senescence, autophagy, and autoimmune and inflammatory diseases. Biochemical and structural studies have elucidated the mechanism of signal transduction in the cGAS pathway at the atomic resolution. This review focuses on the structural and mechanistic insights into the roles of cGAS and STING in immunity and diseases revealed by these recent studies.
AB - Besides its role as the blueprint of life, DNA can also alert the cell to the presence of microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that triggers the innate immune response is cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase (cGAS), which produces the second messenger cGAMP. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators. Recent research has demonstrated an expanding role of the cGAS-cGAMP-STING pathway in many physiological and pathological processes, including host defense against microbial infections, anti-tumor immunity, cellular senescence, autophagy, and autoimmune and inflammatory diseases. Biochemical and structural studies have elucidated the mechanism of signal transduction in the cGAS pathway at the atomic resolution. This review focuses on the structural and mechanistic insights into the roles of cGAS and STING in immunity and diseases revealed by these recent studies.
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U2 - 10.1016/j.immuni.2020.05.013
DO - 10.1016/j.immuni.2020.05.013
M3 - Review article
C2 - 32668227
AN - SCOPUS:85087784647
SN - 1074-7613
VL - 53
SP - 43
EP - 53
JO - Immunity
JF - Immunity
IS - 1
ER -