Structure of vacuolar proton pumps

Dennis K. Stone, Bill P. Crider, Xie Xiao-Song Xie

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


At the present time, knowledge of the structure of the proton-translocating ATPase responsible for urinary acidification is far from complete. Key issues awaiting resolution are full definition of sub-unit structure and an understanding of the interactions among functional domains of this complex hetero-oligomer. Such a detailed analysis is required to begin study of the biogenesis of the vacuolar proton pump and to elucidate the complexities of its molecular regulation.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalSeminars in nephrology
Issue number2
StatePublished - Mar 1990

ASJC Scopus subject areas

  • Nephrology


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