Structure of the low-density lipoprotein receptor-related protein (LRP) promoter

Heike Kütt; Joachim Herz; Keith K. Stanley

doi:10.1016/0167-4781(89)90107-3

Structure of the low-density lipoprotein receptor-related protein (LRP) promoter

Heike Kütt, Joachim Herz, Keith K. Stanley

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48 Scopus citations

Abstract

The low-density Lipoprotein receptor-related protein (LRP) is a 4544-amino-acid membrane protein which closely resembles the LDL receptor in its arrangement of cysteine-rich motifs. Binding studies have suggested that one function of the molecule is as a receptor for ligands containing apolipoprotein E. We present here the sequence and structure of the promoter region of the LRP. These data show that the LRP contains no sterol regulatory element, and is not down-regulated by sterols like the LDL receptor. This lends further support to the identity of the LRP as a chylomicron remnant receptor.

Original language	English (US)
Pages (from-to)	229-236
Number of pages	8
Journal	BBA - Gene Structure and Expression
Volume	1009
Issue number	3
DOIs	https://doi.org/10.1016/0167-4781(89)90107-3
State	Published - Dec 22 1989

Keywords

Apolipoprotein E receptor
LRP promoter
Lipoprotein receptor
Low density lipoprotein
Promoter

ASJC Scopus subject areas

Structural Biology
Biophysics
Biochemistry
Genetics

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10.1016/0167-4781(89)90107-3

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AU - Kütt, Heike

AU - Herz, Joachim

AU - Stanley, Keith K.

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Y1 - 1989/12/22

N2 - The low-density Lipoprotein receptor-related protein (LRP) is a 4544-amino-acid membrane protein which closely resembles the LDL receptor in its arrangement of cysteine-rich motifs. Binding studies have suggested that one function of the molecule is as a receptor for ligands containing apolipoprotein E. We present here the sequence and structure of the promoter region of the LRP. These data show that the LRP contains no sterol regulatory element, and is not down-regulated by sterols like the LDL receptor. This lends further support to the identity of the LRP as a chylomicron remnant receptor.

AB - The low-density Lipoprotein receptor-related protein (LRP) is a 4544-amino-acid membrane protein which closely resembles the LDL receptor in its arrangement of cysteine-rich motifs. Binding studies have suggested that one function of the molecule is as a receptor for ligands containing apolipoprotein E. We present here the sequence and structure of the promoter region of the LRP. These data show that the LRP contains no sterol regulatory element, and is not down-regulated by sterols like the LDL receptor. This lends further support to the identity of the LRP as a chylomicron remnant receptor.

KW - Apolipoprotein E receptor

KW - LRP promoter

KW - Lipoprotein receptor

KW - Low density lipoprotein

KW - Promoter

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Structure of the low-density lipoprotein receptor-related protein (LRP) promoter

Abstract

Keywords

ASJC Scopus subject areas

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