Structure of a Yeast 40S-eIF1-eIF1A-eIF3-eIF3j initiation complex

Christopher H.S. Aylett, Daniel Boehringer, Jan P. Erzberger, Tanja Schaefer, Nenad Ban

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Eukaryotic translation initiation requires cooperative assembly of a large protein complex at the 40S ribosomal subunit. We have resolved a budding yeast initiation complex by cryo-EM, allowing placement of prior structures of eIF1, eIF1A, eIF3a, eIF3b and eIF3c. Our structure highlights differences in initiation-complex binding to the ribosome compared to that of mammalian eIF3, demonstrates a direct contact between eIF3j and eIF1A and reveals the network of interactions between eIF3 subunits.

Original languageEnglish (US)
Pages (from-to)269-271
Number of pages3
JournalNature Structural and Molecular Biology
Issue number3
StatePublished - Mar 6 2015

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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