Abstract
The α and β subunits of the murine I-A alloantigens from several H-2 haplotypes were examined by comparative tryptic peptide mapping by using double label ( 3H and 14C) techniques. Significant structural variation between alleles was detected in both subunits. Tryptic digests of the α polypeptides from s, b, and d showed only 65% co-elution with k; β-chains from s, b, d, and r were about 50% similar to the k β subunit. Peptide analysis of the A(k) subunits from intra-H-2 recombinant strains indicated that both the α and β polypeptides are encoded within the I-A subregion.
Original language | English (US) |
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Pages (from-to) | 2799-2804 |
Number of pages | 6 |
Journal | Journal of Immunology |
Volume | 123 |
Issue number | 6 |
State | Published - 1979 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology