TY - JOUR
T1 - Structural genomics
T2 - keeping up with expanding knowledge of the protein universe
AU - Grabowski, Marek
AU - Joachimiak, Andrzej
AU - Otwinowski, Zbyszek
AU - Minor, Wladek
N1 - Funding Information:
We would like to thank Ian Wilson, Alex Wlodawer, Adam Godzik and Matt Zimmerman for helpful discussions. This work has been supported, in part, by NIH grant GM074942. The authors are members of the Midwest Center for Structural Genomics consortium.
PY - 2007/6
Y1 - 2007/6
N2 - Structural characterization of the protein universe is the main mission of Structural Genomics (SG) programs. However, progress in gene sequencing technology, set in motion in the 1990s, has resulted in rapid expansion of protein sequence space - a twelvefold increase in the past seven years. For the SG field, this creates new challenges and necessitates a re-assessment of its strategies. Nevertheless, despite the growth of sequence space, at present nearly half of the content of the Swiss-Prot database and over 40% of Pfam protein families can be structurally modeled based on structures determined so far, with SG projects making an increasingly significant contribution. The SG contribution of new Pfam structures nearly doubled from 27.2% in 2003 to 51.6% in 2006.
AB - Structural characterization of the protein universe is the main mission of Structural Genomics (SG) programs. However, progress in gene sequencing technology, set in motion in the 1990s, has resulted in rapid expansion of protein sequence space - a twelvefold increase in the past seven years. For the SG field, this creates new challenges and necessitates a re-assessment of its strategies. Nevertheless, despite the growth of sequence space, at present nearly half of the content of the Swiss-Prot database and over 40% of Pfam protein families can be structurally modeled based on structures determined so far, with SG projects making an increasingly significant contribution. The SG contribution of new Pfam structures nearly doubled from 27.2% in 2003 to 51.6% in 2006.
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U2 - 10.1016/j.sbi.2007.06.003
DO - 10.1016/j.sbi.2007.06.003
M3 - Review article
C2 - 17587562
AN - SCOPUS:34347393442
SN - 0959-440X
VL - 17
SP - 347
EP - 353
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
IS - 3
ER -