Structural drift: A possible path to protein fold change

S. Sri Krishna, Nick V. Grishin

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Summary: Along with their mutating sequences, protein structures change in time. Analyzing a formate dehydrogenase domain that is evolutionarily related to ferredoxin, but simultaneously contains all the structural elements of a β-Grasp fold, we illustrate here a mechanism termed as structural drift, by which changes to a protein fold can occur.

Original languageEnglish (US)
Pages (from-to)1308-1310
Number of pages3
Issue number8
StatePublished - Apr 15 2005

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics


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