Abstract
Bratkowski et al. describe cryo-EM structures of autoinhibited and active SARM1, an axon-enriched, injury-activated NADase. Structure-function studies elucidate the mode of autoinhibition and SARM1 activity regulation. The authors provide mechanistic insight into SARM1’s regulation by the local metabolic environment, laying the foundation for future SARM1-based therapies to treat neurological diseases.
Original language | English (US) |
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Article number | 107999 |
Journal | Cell Reports |
Volume | 32 |
Issue number | 5 |
DOIs | |
State | Published - Aug 4 2020 |
Keywords
- NAD hydrolase
- NAM
- NMN
- SARM1
- autoinhibition
- axon
- axonopathies
- cryo-EM
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology