Abstract
Activation of STING requires its translocation from the endoplasmic reticulum (ER) through the Golgi to vesicles, but the mechanisms that control its localization have been unclear. The ER calcium sensor STIM1 acts as an ER-retention factor that anchors STING on the ER and limits STING signaling.
Original language | English (US) |
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Pages (from-to) | 112-114 |
Number of pages | 3 |
Journal | Nature Immunology |
Volume | 20 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2019 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology