Stevens-Johnson syndrome and toxic epidermal necrolysis

Natasha Klimas, Josephine Quintanilla-Dieck, Travis Vandergriff

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Erythema multiforme in its most extreme form has traditionally been divided between toxic epidermal necrolysis and Stevens-Johnson Syndrome. These two life-threatening skin diseases are now considered part of the same spectrum of disease. They can be differentiated by clinical and histological criteria. We can also now predict which patients are apt to have the most guarded prognosis. Treatment by multiple agents is imperfect, but offers a better chance of a good outcome than ever before.

Original languageEnglish (US)
Title of host publicationCutaneous Drug Eruptions
Subtitle of host publicationDiagnosis, Histopathology and Therapy
PublisherSpringer-Verlag London Ltd
Number of pages11
ISBN (Electronic)9781447167297
ISBN (Print)9781447167280
StatePublished - Aug 21 2015


  • "Target" lesions
  • "Wet paper" appearance
  • Apoptosis
  • Asboe-Hanson sign
  • Histocompatibility complex
  • IVIG
  • Immune memory
  • Plasmapheresis

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Immunology and Microbiology(all)


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