Stevens-Johnson syndrome and toxic epidermal necrolysis

Natasha Klimas; Josephine Quintanilla-Dieck; Travis Vandergriff

doi:10.1007/978-1-4471-6729-7_24

Stevens-Johnson syndrome and toxic epidermal necrolysis

Natasha Klimas, Josephine Quintanilla-Dieck, Travis Vandergriff

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Erythema multiforme in its most extreme form has traditionally been divided between toxic epidermal necrolysis and Stevens-Johnson Syndrome. These two life-threatening skin diseases are now considered part of the same spectrum of disease. They can be differentiated by clinical and histological criteria. We can also now predict which patients are apt to have the most guarded prognosis. Treatment by multiple agents is imperfect, but offers a better chance of a good outcome than ever before.

Original language	English (US)
Title of host publication	Cutaneous Drug Eruptions
Subtitle of host publication	Diagnosis, Histopathology and Therapy
Publisher	Springer-Verlag London Ltd
Pages	259-269
Number of pages	11
ISBN (Electronic)	9781447167297
ISBN (Print)	9781447167280
DOIs	https://doi.org/10.1007/978-1-4471-6729-7_24
State	Published - Aug 21 2015

Keywords

"Target" lesions
"Wet paper" appearance
Apoptosis
Asboe-Hanson sign
Histocompatibility complex
IVIG
Immune memory
Plasmapheresis

ASJC Scopus subject areas

Medicine(all)
Pharmacology, Toxicology and Pharmaceutics(all)
Immunology and Microbiology(all)

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10.1007/978-1-4471-6729-7_24

Cite this

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AU - Quintanilla-Dieck, Josephine

AU - Vandergriff, Travis

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AB - Erythema multiforme in its most extreme form has traditionally been divided between toxic epidermal necrolysis and Stevens-Johnson Syndrome. These two life-threatening skin diseases are now considered part of the same spectrum of disease. They can be differentiated by clinical and histological criteria. We can also now predict which patients are apt to have the most guarded prognosis. Treatment by multiple agents is imperfect, but offers a better chance of a good outcome than ever before.

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KW - "Wet paper" appearance

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KW - Asboe-Hanson sign

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KW - Immune memory

KW - Plasmapheresis

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BT - Cutaneous Drug Eruptions

PB - Springer-Verlag London Ltd

ER -

Stevens-Johnson syndrome and toxic epidermal necrolysis

Abstract

Keywords

ASJC Scopus subject areas

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